|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We analyzed levels of IL-20 receptor subunit A (IL-20RA), CD55, and receptor activator of nuclear factor kappaB (NF-κB) ligand (RANKL) in RA fibroblast-like synoviocytes (FLSs) using confocal microscopy.
|
31831038 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The developed theranostic AuMB complexes could not only provide excellent US and NIRF imaging to detect tumors but also serve as an efficient US-triggered carrier for gene delivery and photothermal ablation of tumors in xenografted nude mice.
|
31525534 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
NIRF turn-on nanoparticles based on the tumor microenvironment for monitoring intracellular protein delivery.
|
31769770 |
2019 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory bone disorders likes intervertebral disc herniation, rheumatoid arthritis (RA), osteoporosis, and bone fracture.
|
30250404 |
2018 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis.
|
30319661 |
2018 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory disorders likes psoriasis, atherosclerosis, cancer, liver fibrosis, and RA.
|
29690863 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
By contrast, IL-17B is reported to be closely related to certain diseases, particularly tumors such as breast cancer, gastric cancer, and pancreatic cancer.
|
30345318 |
2018 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory disorders likes psoriasis, atherosclerosis, cancer, liver fibrosis, and RA.
|
29690863 |
2018 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory disorders likes psoriasis, atherosclerosis, and renal failure.
|
29999545 |
2018 |
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of IL-20 in RA synovial tissue was particularly associated with macrophages and neutrophil granulocytes, but also with synovial fibroblasts and lymphocytes.
|
28662439 |
2017 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review focuses on current knowledge of IL-20's involvement in the pathogenesis of rheumatoid arthritis.
|
26297177 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In-vivo NIRF optical imaging and ex-vivo confocal microscopy were used to assess the biodistribution of GSK2849330 and the HER3 receptor occupancy in HER3 positive xenograft tumors (BxPC3, and CHL-1).
|
28448604 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, the biological function of IL-17B in diseases, particularly tumors, has attracted the attention of researchers.
|
28704706 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
HCC tumor tissue expressed higher levels of IL-20 than did non-tumor tissue.
|
29242565 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study, we further explored the effect of IL-17B on mesenchymal stem cells in tumor microenvironment and its impact on the tumor progression.
|
28145881 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore, GPC@ NIRF-Fe<sub>3</sub>O<sub>4</sub> NPs may be potentially used as a candidate for dual-modal imaging of tumors with information covalidated and directly compared by combining fluorescence and MR imaging.
|
28352173 |
2017 |
|
Psoriasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interleukin (IL)-10 family cytokines IL-10, IL-19, IL-20 and IL-24 have been implicated in autoimmune diseases and we have previously reported that genetic variants in the IL10 gene cluster were associated with psoriasis.
|
28150860 |
2017 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The IL-20 subfamily of cytokines has been reported to act at epithelial sites and contribute to psoriasis, wound healing, and anti-inflammatory effects during <i>S. aureus</i> infection.
|
28424238 |
2017 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Elucidation of this interaction provides a better understanding of cytokine cross-talk in RA and a rationale for more effective biologic therapies that target IL-20R2 instead of individual cytokines from IL-20 family.
|
27619991 |
2016 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results highlight the importance of gene assignment for translating GWAS findings into biologically meaningful mechanisms of disease and potential therapeutic targets; indeed, monoclonal antibody therapy targeting IL-20 is effective in the treatment of rheumatoid arthritis and psoriasis, both with strong GWAS associations to this region.
|
27799070 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Using NIRF imaging millimetre sized tumour nodules were detected that were invisible for the naked eye.
|
27842504 |
2016 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results highlight the importance of gene assignment for translating GWAS findings into biologically meaningful mechanisms of disease and potential therapeutic targets; indeed, monoclonal antibody therapy targeting IL-20 is effective in the treatment of rheumatoid arthritis and psoriasis, both with strong GWAS associations to this region.
|
27799070 |
2016 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-20 is involved in the development of skin psoriasis.
|
26176762 |
2015 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present review, we focus on IL-7, IL-18, IL-32 and IL-10 family of cytokines (IL-19, IL-20 and IL-22) as they are implicated in contributing to the pathogenesis of RA, which could be targeted and offer new therapeutic options for RA therapy.
|
24437572 |
2014 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent evidence indicates that IL-20's interaction with its receptors might have proinflammatory effects on chronic inflammatory diseases, particularly rheumatoid arthritis (RA), osteoporosis, and breast cancer.
|
24816455 |
2014 |