Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010606
Disease: Adenoid Cystic Carcinoma
Adenoid Cystic Carcinoma
0.300 Biomarker disease CTD_human Genes associated with early development, apoptosis and cell cycle regulation define a gene expression profile of adenoid cystic carcinoma. 16762588 2006
CUI: C0036095
Disease: Salivary Gland Neoplasms
Salivary Gland Neoplasms
0.300 Biomarker group CTD_human Genes associated with early development, apoptosis and cell cycle regulation define a gene expression profile of adenoid cystic carcinoma. 16762588 2006
Malignant neoplasm of salivary gland
0.300 Biomarker disease CTD_human Genes associated with early development, apoptosis and cell cycle regulation define a gene expression profile of adenoid cystic carcinoma. 16762588 2006
CUI: C0011175
Disease: Dehydration
Dehydration
0.200 Biomarker phenotype RGD Dehydration-induced proteome changes in the rat hypothalamo-neurohypophyseal system. 17412804 2007
CUI: C0028754
Disease: Obesity
Obesity
0.200 Biomarker disease RGD Obesity and diabetes in transgenic mice expressing proSAAS. 15012590 2004
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.020 Biomarker group BEFREE The goal of this study is to explore the mechanism of a heat shock protein 90 (Hsp90) C-terminal inhibitor, Penicisulfuranol A (PEN-A), for cancer therapy. 30857829 2019
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.020 Biomarker group BEFREE The goal of this study is to explore the mechanism of a heat shock protein 90 (Hsp90) C-terminal inhibitor, Penicisulfuranol A (PEN-A), for cancer therapy. 30857829 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.020 Biomarker group BEFREE Using SAAS-CNV to Detect and Characterize Somatic Copy Number Alterations in Cancer Genomes from Next Generation Sequencing and SNP Array Data. 30039361 2018
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.020 Biomarker group BEFREE Using SAAS-CNV to Detect and Characterize Somatic Copy Number Alterations in Cancer Genomes from Next Generation Sequencing and SNP Array Data. 30039361 2018
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.020 Biomarker disease BEFREE Taken together, our results suggest that proSAAS may play a role in Alzheimer's disease pathology. 24102330 2014
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.020 Biomarker disease LHGDN A human granin-like neuroendocrine peptide precursor (proSAAS) immunoreactivity in tau inclusions of Alzheimer's disease and parkinsonism-dementia complex on Guam. 14746899 2004
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.010 Biomarker disease BEFREE This study used semi-structured interviews of women attending a cancer screening facility in Lagos, Nigeria guided by the PEN-3 model to describe culturally relevant factors that shape attitudes toward breast cancer and breast cancer screening. 28678532 2019
CUI: C0016053
Disease: Fibromyalgia
Fibromyalgia
0.010 AlteredExpression disease BEFREE ProSAAS is one of the most widely expressed proteins throughout the brain and was recently found to be upregulated in chronic fibromyalgia patients. 31308196 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.010 Biomarker group BEFREE 'I believe high blood pressure can kill me:' using the PEN-3 Cultural Model to understand patients' perceptions of an intervention to control hypertension in Ghana. 28675047 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.010 AlteredExpression group BEFREE PEN-221 targets high levels of DM1 to SSTR2-expressing xenograft tumors, which has led to tumor regressions in several SSTR2-expressing xenograft mouse models. 30735385 2019
CUI: C0030193
Disease: Pain
Pain
0.010 Biomarker phenotype BEFREE Although BigLEN-GPR171 has been found to play a role in feeding and anxiety behaviors, it has not yet been explored in pain and opioid modulation. 31308196 2019
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung
0.010 AlteredExpression disease BEFREE PEN-221 treatment resulted in significant antitumor activity, including complete regressions in SSTR2-positive SCLC xenograft mouse models. 31649014 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.010 Biomarker disease BEFREE This study used semi-structured interviews of women attending a cancer screening facility in Lagos, Nigeria guided by the PEN-3 model to describe culturally relevant factors that shape attitudes toward breast cancer and breast cancer screening. 28678532 2019
CUI: C1285498
Disease: Vegetation
Vegetation
0.010 Biomarker disease BEFREE In the EE studies, PEN alone failed to clear <i>S. mitis</i> from vegetations, while ceftriaxone and vancomycin were significantly more effective (<i>P</i> < 0.001). 31182540 2019
CUI: C1510472
Disease: Drug Dependence
Drug Dependence
0.010 Biomarker group BEFREE As studies have suggested a role for the PEN-GPR83 system in food intake and body weight regulation, as well as in drug addiction and reward disorders, a thorough understanding of this novel neuropeptide-receptor system will help identify novel therapeutic targets to treat pathophysiological conditions involving PEN-GPR83. 30726666 2019
Diabetes Mellitus, Insulin-Dependent
0.010 GeneticVariation disease BEFREE Factors Affecting Self-Care Performance in Adolescents with Type I Diabetes According to the PEN-3 Cultural Model. 30464772 2018
CUI: C0162429
Disease: Malnutrition
Malnutrition
0.010 GeneticVariation disease BEFREE Malnutrition among older adults living in Portuguese nursing homes: the PEN-3S study. 30319081 2018
CUI: C0003467
Disease: Anxiety
Anxiety
0.010 AlteredExpression disease BEFREE Our findings provide initial support for the use of the SWAP-SAAS as a therapist-rated measure associated with lower patient-reported levels of fit with a secure attachment prototype and with higher patient-reported levels of attachment anxiety. 28863304 2017
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.010 AlteredExpression group BEFREE Our findings provide initial support for the use of the SWAP-SAAS as a therapist-rated measure associated with lower patient-reported levels of fit with a secure attachment prototype and with higher patient-reported levels of attachment anxiety. 28863304 2017
CUI: C0004936
Disease: Mental disorders
Mental disorders
0.010 Biomarker group BEFREE These results indicate that the BigLEN-GPR171 system plays an important role in these behaviors and could be a novel target to develop therapeutics to treat psychiatric disorders. 28425495 2017