Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A mutation in Patched, Smoothened or Gli1, which regulate the Hh signaling pathway, might lead to the onset of glioblastoma, basal cell carcinoma, medulloblastoma and rhabdomyosarcoma.
|
21679342 |
2011 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion.
|
19706761 |
2009 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Activity of Metabotropic Glutamate Receptor 4 Suppresses Proliferation and Promotes Apoptosis With Inhibition of Gli-1 in Human Glioblastoma Cells.
|
29867331 |
2018 |
Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Administration of baicalin upregulated the expression of sonic hedgehog (Shh), patched (Ptc), Smoothened (Smo), and Glioblastoma-1(Gli-1).
|
27576501 |
2016 |
Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
After polydatin treatment, the main components of the Shh pathway, including Shh, Patched (Ptc), Smoothened (Smo), and glioblastoma-1 (Gli1), were upregulated at the mRNA and protein levels.
|
30218952 |
2018 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although the GLI1 gene was initially identified as an amplified gene in glioblastoma, its amplification was found to be relatively rare.
|
22369969 |
2012 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Combination therapy with micellarized cyclopamine and temozolomide attenuate glioblastoma growth through Gli1 down-regulation.
|
28477008 |
2017 |
Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Cyclopamine treatment effectively increased apoptosis and inhibited cell proliferation, migration, and epithelial-to-mesenchymal transition (EMT) by downregulating the Hh final arbiter glioblastoma 1 (Gli1), which regulates the transcription of target genes in the nucleus.
|
24553082 |
2014 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma.
|
17628016 |
2007 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Effects of different combinations of VIP-related neuropeptides and of pharmacological and siRNA inhibitors of PKA, Akt, and of the SHH/GLI1 pathways were tested on GBM migration rat C6 and human U87 GBM cell lines using the wound-healing technique.
|
30669581 |
2019 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Further investigation found that the expression of the glioblastoma transcription factor (Gli) significantly increased in TGF-β1-stimulated neuroblastoma cells undergoing EMT, accordingly, interfering with Gli1/2 expression inhibited TGF-β1-induced EMT in neuroblastoma cells.
|
28393230 |
2017 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Hedgehog signaling pathway is active in GBM with GLI1 mRNA expression showing a single continuous distribution rather than discrete high/low clusters.
|
25775002 |
2015 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Hepatic expression of IGFBPrP1, α-smooth muscle actin (α-SMA), transforming growth factor β 1 (TGFβ1), collagen I, MMPs/TIMPs, Sonic Hedgehog (Shh), and glioblastoma family transcription factors (Gli1) were investigated by immunohistochemical staining and Western blotting analysis.
|
30243878 |
2019 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we found that FOXM1 promotes nuclear import of GLI1 in glioblastoma multiforme cells and thus increases the expression of its target genes.
|
26085085 |
2015 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Herein, we report that TGLI1 had a higher propensity than GLI1 to enhance glioblastoma angiogenesis and growth, both in vivo and in vitro.
|
24045042 |
2014 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In an orthotopic GBM xenograft mouse model, tGLI1-overexpressing tumors grew more aggressively with increased proliferation and angiogenesis compared with control and GLI1-overexpressing xenografts. tGLI1 was highly expressed in GBM clinical specimens but undetectable in normal brains, whereas GLI1 was expressed in both tissues.
|
29463580 |
2018 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In summary, our study reveals that the USP48-Gli1 regulatory axis is critical for glioma cell proliferation and glioblastoma tumorigenesis.
|
28623188 |
2017 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we compared TGLI1- with GLI1-expressing GBM xenografts for the expression profile of 84 angiogenesis-associated genes.
|
26093087 |
2015 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
O<sup>6</sup>-Methylguanine DNA methyltransferase-positive GBM tissues had a significantly higher rate of Gli1 nuclear staining than MGMT-negative ones (67.7% vs. 32.3%, p = 0.0159).
|
29225516 |
2017 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our data indicate that upregulation of GLI1 induced by QKI deficiency maintains GSC stemness and enhances the invasiveness of GBM cells, thereby hinting at new options for the treatment of GBM.
|
31292920 |
2019 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Polyethylenimine-Spherical Nucleic Acid Nanoparticles against Gli1 Reduce the Chemoresistance and Stemness of Glioblastoma Cells.
|
30260647 |
2018 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Southern blot analysis revealed amplification of the GLI oncogene in two of the glioblastomas which were found to contain amplified domains within 12q13-15.
|
7654443 |
1994 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Subsequently, GLI was found to be amplified in other human glioblastomas (ref.3 and unpublished data).
|
2832761 |
1988 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our results indicate that overall glioblastoma tumor growth suppression by penfluridol was associated with Akt-mediated inhibition of GLI1.
|
28380428 |
2017 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The human GLI1 gene was identified in 1987 as an amplified gene in glioblastoma.
|
22391302 |
2012 |