Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data suggested that FL34 exerted antitumor activity mediated by the inhibition of GLI1 and that FL34 may be a potential antitumor candidate compound that could be used to develop new antitumor drugs for the treatment of GBM.
|
31436248 |
2019 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Effects of different combinations of VIP-related neuropeptides and of pharmacological and siRNA inhibitors of PKA, Akt, and of the SHH/GLI1 pathways were tested on GBM migration rat C6 and human U87 GBM cell lines using the wound-healing technique.
|
30669581 |
2019 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Hepatic expression of IGFBPrP1, α-smooth muscle actin (α-SMA), transforming growth factor β 1 (TGFβ1), collagen I, MMPs/TIMPs, Sonic Hedgehog (Shh), and glioblastoma family transcription factors (Gli1) were investigated by immunohistochemical staining and Western blotting analysis.
|
30243878 |
2019 |
Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The mRNA and protein levels of Shh, glioblastoma-1 (Gli1), and smoothened (SMO) were determined by RT-qPCR and western blot analysis, respectively.
|
31773440 |
2019 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our data indicate that upregulation of GLI1 induced by QKI deficiency maintains GSC stemness and enhances the invasiveness of GBM cells, thereby hinting at new options for the treatment of GBM.
|
31292920 |
2019 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We generated an antibody specific for phosphorylated PD-1-Y248 and examined PD-1pY248<sup>+</sup> (pPD-1) expression in human T cells. pPD-1 was upregulated by TCR/CD3 + CD28 stimulation and simultaneous PD-1 ligation. pPD-1<sup>+</sup>CD8<sup>+</sup> T cells were identified in human peripheral blood and had impaired effector function. pPD-1<sup>+</sup> T cells were also detected in tumor-draining lymph nodes of tumor bearing mice and in biopsies of patients with glioblastoma multiform.
|
31754127 |
2019 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Activity of Metabotropic Glutamate Receptor 4 Suppresses Proliferation and Promotes Apoptosis With Inhibition of Gli-1 in Human Glioblastoma Cells.
|
29867331 |
2018 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Polyethylenimine-Spherical Nucleic Acid Nanoparticles against Gli1 Reduce the Chemoresistance and Stemness of Glioblastoma Cells.
|
30260647 |
2018 |
Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
After polydatin treatment, the main components of the Shh pathway, including Shh, Patched (Ptc), Smoothened (Smo), and glioblastoma-1 (Gli1), were upregulated at the mRNA and protein levels.
|
30218952 |
2018 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In an orthotopic GBM xenograft mouse model, tGLI1-overexpressing tumors grew more aggressively with increased proliferation and angiogenesis compared with control and GLI1-overexpressing xenografts. tGLI1 was highly expressed in GBM clinical specimens but undetectable in normal brains, whereas GLI1 was expressed in both tissues.
|
29463580 |
2018 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In summary, our study reveals that the USP48-Gli1 regulatory axis is critical for glioma cell proliferation and glioblastoma tumorigenesis.
|
28623188 |
2017 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We aimed to investigate the effect of GLI1 expression in glioblastoma focusing on the nuclear localization.
|
28417299 |
2017 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Combination therapy with micellarized cyclopamine and temozolomide attenuate glioblastoma growth through Gli1 down-regulation.
|
28477008 |
2017 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
O<sup>6</sup>-Methylguanine DNA methyltransferase-positive GBM tissues had a significantly higher rate of Gli1 nuclear staining than MGMT-negative ones (67.7% vs. 32.3%, p = 0.0159).
|
29225516 |
2017 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Further investigation found that the expression of the glioblastoma transcription factor (Gli) significantly increased in TGF-β1-stimulated neuroblastoma cells undergoing EMT, accordingly, interfering with Gli1/2 expression inhibited TGF-β1-induced EMT in neuroblastoma cells.
|
28393230 |
2017 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our results indicate that overall glioblastoma tumor growth suppression by penfluridol was associated with Akt-mediated inhibition of GLI1.
|
28380428 |
2017 |
Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Administration of baicalin upregulated the expression of sonic hedgehog (Shh), patched (Ptc), Smoothened (Smo), and Glioblastoma-1(Gli-1).
|
27576501 |
2016 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we compared TGLI1- with GLI1-expressing GBM xenografts for the expression profile of 84 angiogenesis-associated genes.
|
26093087 |
2015 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we found that FOXM1 promotes nuclear import of GLI1 in glioblastoma multiforme cells and thus increases the expression of its target genes.
|
26085085 |
2015 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Hedgehog signaling pathway is active in GBM with GLI1 mRNA expression showing a single continuous distribution rather than discrete high/low clusters.
|
25775002 |
2015 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Herein, we report that TGLI1 had a higher propensity than GLI1 to enhance glioblastoma angiogenesis and growth, both in vivo and in vitro.
|
24045042 |
2014 |
Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Cyclopamine treatment effectively increased apoptosis and inhibited cell proliferation, migration, and epithelial-to-mesenchymal transition (EMT) by downregulating the Hh final arbiter glioblastoma 1 (Gli1), which regulates the transcription of target genes in the nucleus.
|
24553082 |
2014 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although the GLI1 gene was initially identified as an amplified gene in glioblastoma, its amplification was found to be relatively rare.
|
22369969 |
2012 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The human GLI1 gene was identified in 1987 as an amplified gene in glioblastoma.
|
22391302 |
2012 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A mutation in Patched, Smoothened or Gli1, which regulate the Hh signaling pathway, might lead to the onset of glioblastoma, basal cell carcinoma, medulloblastoma and rhabdomyosarcoma.
|
21679342 |
2011 |