BIN1, bridging integrator 1, 274

N. diseases: 163; N. variants: 24
Disease: Ulcerative Colitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.030 Biomarker disease BEFREE Recently our group found Bin1 antibody could exert drug-like properties in an animal model of ulcerative colitis. 31211444 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.030 Biomarker disease BEFREE Overall, our results suggest that Bin1 mAb protects against UC by directly improving colonic epithelial barrier function to limit gene expression and cytokine programs associated with colonic inflammation. 30269357 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.030 Biomarker disease BEFREE In this study, we offer preclinical proof of concept for a monoclonal antibody (mAb) targeting the Bin1 protein that blunts UC pathogenicity in a mouse model of experimental colitis. 26195312 2016