BIN1, bridging integrator 1, 274

N. diseases: 163; N. variants: 24
Disease: Memory impairment ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.020 Biomarker phenotype BEFREE In TgMAPT;TgBIN1 mice short-term memory deficits appeared earlier than in TgMAPT mice; however-unlike TgMAPT mice-TgMAPT;TgBIN1 mice did not exhibit any long-term or spatial memory deficits for at least 15 months. 31065832 2019
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.020 GeneticVariation phenotype BEFREE Together, our findings suggest that the BIN1 rs744373 SNP is associated with increased tau but not beta-amyloid pathology, suggesting that alterations in BIN1 may contribute to memory deficits via increased tau pathology. 30992433 2019