GLP1R, glucagon like peptide 1 receptor, 2740

N. diseases: 288; N. variants: 7
Disease: Malignant Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.330 Biomarker group BEFREE GLP-1 receptor agonists and risk of cancer in type 2 diabetes: an updated meta-analysis of randomized controlled trials. 31420784 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.330 Biomarker group BEFREE Compounds 1 and 2 displayed high affinities to target proteins GLP-1R (diabetes) and eEF2K (cancer) with K<sub>d</sub> values of 0.0285 μM, 0.0162 μM for GLP-1R and 0.118 μM, 0.0746 μM for eEF2K, respectively. 30990084 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.330 Biomarker group BEFREE At ≤20°C, glp-1(ar202) is wild-type, whereas at 25°C it forms a germline stem cell⁄progenitor cell tumor reminiscent of human cancer. 26120834 2015
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.330 Biomarker group CTD_human On-target effects of GLP-1 receptor agonists on thyroid C-cells in rats and mice. 23471186 2013