PONTOCEREBELLAR HYPOPLASIA TYPE 3 (disorder)
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Loss of PCLO function underlies pontocerebellar hypoplasia type III.
|
25832664 |
2015 |
PONTOCEREBELLAR HYPOPLASIA TYPE 3 (disorder)
|
0.700 |
GermlineCausalMutation
|
disease |
ORPHANET |
Loss of PCLO function underlies pontocerebellar hypoplasia type III.
|
25832664 |
2015 |
PONTOCEREBELLAR HYPOPLASIA TYPE 3 (disorder)
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Loss of PCLO function underlies pontocerebellar hypoplasia type III.
|
25832664 |
2015 |
PONTOCEREBELLAR HYPOPLASIA TYPE 3 (disorder)
|
0.700 |
Biomarker
|
disease |
CTD_human |
|
|
|
PONTOCEREBELLAR HYPOPLASIA TYPE 3 (disorder)
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Major Depressive Disorder
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.
|
30718901 |
2019 |
Major Depressive Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Among the individuals carrying the C-allele of PCLO rs2522833, the volume of the left temporal pole was significantly smaller in those with MDD than in healthy controls (family-wise error-corrected, P=0.003).
|
28556829 |
2017 |
Major Depressive Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our results confirm the potential role of the PCLO gene in MDD, which is worth further replication and functional studies.
|
28540843 |
2017 |
Major Depressive Disorder
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-Wide Significance for PCLO as a Gene for Major Depressive Disorder.
|
28540843 |
2017 |
Major Depressive Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Functional characterization of the PCLO p.Ser4814Ala variant associated with major depressive disorder reveals cellular but not behavioral differences.
|
26045179 |
2015 |
Major Depressive Disorder
|
0.500 |
Biomarker
|
disease |
PSYGENET |
Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression.
|
24643163 |
2014 |
Major Depressive Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression.
|
24643163 |
2014 |
Major Depressive Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Although we did not take into account rare variants, we conclude that our results provide further support for the hypothesis that the non-synonymous coding SNP rs2522833 in the PCLO gene is indeed likely to be the causal variant in the GAIN-MDD cohort.
|
24278217 |
2013 |
Major Depressive Disorder
|
0.500 |
Biomarker
|
disease |
PSYGENET |
We aimed to gather more evidence that rs2522833 is indeed the causal variant in the GAIN-MDD cohort or to find a previously undetected common variant in either PCLO, GRM7, or SLC6A4 with a higher association in this cohort.
|
24278217 |
2013 |
Major Depressive Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A genome-wide association study implicated the polymorphism rs2522833 in the piccolo (PCLO) gene--involved in monoaminergic neurotransmission--as a risk factor for MDD.
|
22832909 |
2012 |
Major Depressive Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
These results provide further support for the involvement of the PCLO gene in MDD and show that this effect may be mediated by influencing personality traits that increase the risk of major depression.
|
22386049 |
2012 |
Major Depressive Disorder
|
0.500 |
Biomarker
|
disease |
PSYGENET |
These results provide further support for the involvement of the PCLO gene in MDD and show that this effect may be mediated by influencing personality traits that increase the risk of major depression.
|
22386049 |
2012 |
Major Depressive Disorder
|
0.500 |
Biomarker
|
disease |
PSYGENET |
A genome-wide association study implicated the polymorphism rs2522833 in the piccolo (PCLO) gene--involved in monoaminergic neurotransmission--as a risk factor for MDD.
|
22832909 |
2012 |
Major Depressive Disorder
|
0.500 |
Biomarker
|
disease |
PSYGENET |
Recent genetic studies showed evidence for a role of the single-nucleotide polymorphism rs2522833 within the PCLO gene in the etiology of major depression, and rs2522833 has been shown to modulate hypothalamic pituitary adrenal (HPA) axis activity during antidepressant treatment.
|
22832399 |
2011 |
Major Depressive Disorder
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples.
|
21621269 |
2011 |
Major Depressive Disorder
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples.
|
21621269 |
2011 |
Major Depressive Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
PCLO rs2522833 modulates HPA system response to antidepressant treatment in major depressive disorder.
|
20701824 |
2011 |
Major Depressive Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
Previous genome-wide association analysis revealed a new putative candidate gene for major depression: the PCLO gene.
|
19942622 |
2010 |
Major Depressive Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo.
|
19065144 |
2009 |
Major Depressive Disorder
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo.
|
19065144 |
2009 |