GNAL, G protein subunit alpha L, 2774

N. diseases: 41; N. variants: 14
Disease: Movement Disorders ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026650
Disease: Movement Disorders
Movement Disorders 		0.020 GeneticVariation group BEFREE Our results provide evidence that Gα(olf) deficiency intensifies the effects of D2R antagonism and suggests that loss-of-function variants in GNAL may increase risk for movement disorders associated with D2R blockers. 31034808 2019
CUI: C0026650
Disease: Movement Disorders
Movement Disorders 		0.020 GeneticVariation group BEFREE GNAL mutations have been shown to cause adult-onset isolated dystonia, a disabling movement disorder characterized by involuntary muscle contractions causing twisting and repetitive movements or abnormal postures. 24408567 2014