|
Night blindness, congenital stationary
|
0.510 |
GermlineCausalMutation
|
disease |
ORPHANET |
Biallelic Mutations in GNB3 Cause a Unique Form of Autosomal-Recessive Congenital Stationary Night Blindness.
|
27063057 |
2016 |
|
Night blindness, congenital stationary
|
0.510 |
Biomarker
|
disease |
BEFREE |
Homozygosity mapping ruled out most known CSNB candidates as well as CACNA2D4 and GNB3.
|
26368928 |
2015 |
|
Night blindness, congenital stationary
|
0.510 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our study gave a comprehensive insight into functional interaction between GNB3 and eNOS gene polymorphisms and suggests that the eNOS G894T and T-786C variants are strong predisposing factors of VED susceptibility within men with type 2 diabetes.
|
30101547 |
2018 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In our study, there was a significant association between the C825T polymorphism of the GNB3 gene and the occurrence of hypertension (odds ratio 1.275; 95% confidence interval 1.042-1.559; p=0.018) in the dominant model, after multivariate analysis.
|
29853161 |
2018 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To examine the associations of two obesity-associated genes, FTO (rs9939609) and GNB3 (rs5443) single nucleotide polymorphisms (SNPs), with early pregnancy body mass index, gestational weight gain, and postpartum weight retention.
|
29469022 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
GNB3 (C825T) polymorphism is not associated with T2DM.
|
28602143 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.400 |
Biomarker
|
disease |
BEFREE |
GNB3-T/+ mice have elevated fasting plasma glucose, insulin, and C-peptide, as well as glucose intolerance, indicating type 2 diabetes.
|
29206867 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.400 |
Biomarker
|
disease |
BEFREE |
FTO (OR = 1.71; CI<sub>95 %</sub> = 1.14-2.57; p = 0.008) and APOB (OR = 0.31; CI<sub>95 %</sub> = 0.14-0.72; p = 0.004) result is statistically associated to high blood pressure and FTO (OR = 2.0; CI<sub>95 %</sub> = 1.3-3.1; p = 0.001), GNB3 (OR = 2.69; CI<sub>95 %</sub> = 1.0-7.2; p = 0.04), IFI30 (OR = 2.0; CI<sub>95 %</sub> = 1.16-3.6; p = 0.01), and MC4R (OR = 1.81; CI<sub>95 %</sub> = 1.13-2.9; p = 0.01) to type 2 diabetes (T2D).
|
28035522 |
2017 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To test the hypothesis that GNB3 overexpression causes obesity, we created bacterial artificial chromosome (BAC) transgenic mice that carry an extra copy of the human GNB3 risk allele.
|
29206867 |
2017 |
|
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In summary, the present meta-analysis indicated the GNB3 C825T polymorphism is related to increased EH exclusively in Caucasians.
|
28540932 |
2017 |
|
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the current study, 729 patients (CC, n = 332; CT, n = 313; TT, n = 84) with essential hypertension were genotyped for C825T polymorphism of the GNB3 gene and followed 8 years for major adverse cardiovascular events (MACEs) which include stroke, the onset of coronary artery disease (CAD), and all-cause death.
|
28067546 |
2017 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In addition, GNB3 genotypes could be associated with clinical worsening in pulmonary hypertension (PH) treated with PDE-5I.
|
26821322 |
2016 |
|
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The GNB3 splice variant rs5443" genes_norm="2784">C825T (rs5443) is associated with risk for essential hypertension (EH) and efficacy of therapeutic drugs targeting GPCRs.
|
26712426 |
2016 |
|
Essential Hypertension
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results demonstrate the potential use of a GNB3-specific antisense morpholino, as a pharmacogenetic therapy for essential hypertension.
|
27028457 |
2016 |
|
NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1H
|
0.400 |
GeneticVariation
|
disease |
UNIPROT |
Biallelic Mutations in GNB3 Cause a Unique Form of Autosomal-Recessive Congenital Stationary Night Blindness.
|
27063057 |
2016 |
|
Essential Hypertension
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Essential hypertension patients were genotyped for 11 polymorphisms of essential hypertension susceptibility genes including ADD1 (rs4961), GNB3 (rs5443, rs16932941), NOS3 (rs1799983, rs2070744), ACE (rs5186), AGTR1 (rs5186), AGT (rs699, rs4762), MR (rs5534), and TGFB1 (rs1800471).
|
26335431 |
2015 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The C825T polymorphism of the gene encoding the human G protein beta-3 subunit (GNB3) is associated with hypertension and obesity.
|
25463071 |
2014 |
|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
Polymorphisms in Gβ3 (GNB3) are associated with many human disorders (e.g. hypertension, diabetes and obesity) but the role of GNB3 in these pathogeneses remains unclear.
|
25093805 |
2014 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We conclude that the previous cumulative evidence does not support the proposal that haplotypes formed by common GNB3 polymorphisms might contribute either to the development of hypertension and obesity, or to the variation in the SBP, DBP and BMI.
|
24477587 |
2014 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Obesity is known to be influenced by a number of genes, including the β3 subunit of G protein (GNB3), β3-adrenergic receptor (ADRB3), uncoupling protein 2 (UCP2), and peroxisome proliferator activated receptor gamma (PPARγ).
|
24827746 |
2014 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated the associations between the GNB3 C825T polymorphism and obesity-related metabolic risk factors among Korean obese women.
|
25280441 |
2014 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Polymorphisms in Gβ3 (GNB3) are associated with many human disorders (e.g. hypertension, diabetes and obesity) but the role of GNB3 in these pathogeneses remains unclear.
|
25093805 |
2014 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Sensitivity analyses excluding studies violating Hardy-Weinberg expectations, considering gender-specific effects or more extreme phenotypes (e.g. obesity only) as well as a fixed-effects "pooled" analysis also did not disclose a significant influence of GNB3 haplotypes on cardiovascular phenotypes.
|
24477587 |
2014 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The C825T polymorphism of the gene encoding the human G protein beta-3 subunit (GNB3) is associated with hypertension and obesity.
|
25463071 |
2014 |