|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The presented results indicated a potential of the novel tracer [<sup>18</sup>F]FP-d-Lys<sup>6</sup>-GnRH for tumor GnRH receptor imaging.
|
30983920 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The functions of GnRH receptor and its hormone in malignant cells have been related with the decrease of proliferation and the invasiveness of those tumors however, little is known about the molecules associated with the signaling pathways regulated by both molecules in malignant cells.
|
28709956 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
High cell-surface GnRH receptor (GnRH-R) levels have been shown to have a major influence on the extent of GnRH agonist-mediated tumor growth inhibition.
|
23326338 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Using a mouse model of human ovarian cancer metastasis, we found that the inhibition of GnRH receptor, β1 integrin, and P-cadherin significantly attenuated tumor growth, ascites formation, and the number of metastatic implants.
|
23164934 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, using a mouse model of ovarian cancer metastasis, GnRH receptor knockdown was shown to diminish peritoneal dissemination of tumors and ascites formation.
|
21317933 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We also found that GnRH receptor is expressed in glioblastoma tissues from tumor patients as shown by Western blotting.
|
19360304 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we review data on the effects of GnRH agonists on cell proliferation and apoptosis, and put forward hypotheses for investigation to determine whether the GnRH receptor acts as a tumor suppressor in neuroendocrine or epithelial cells.
|
18309229 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The signal transduction pathway in tumor cells is basically different from the classic GnRH receptor signal transduction, which is known to operate in the pituitary gonadotrophs and can therefore be considered tumor specific.
|
15713894 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor DNA was screened for Gsalpha and GnRH receptor gene sequences.
|
15233551 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The level of RGnRH expressed by ovarian cancer might be used for targeting chemotherapeutic agents to those patients who harbor RGnRH-positive tumors.
|
15228417 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
After binding of its ligand the tumor GnRH receptor couples to G-protein alphai and activates a variety of intracellular signaling mechanisms.
|
12790790 |
2003 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Surgically removed tumors and normal tissues had been screened for GnRH receptor expression before analysis.
|
11836606 |
2002 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To provide a potential association of the Fas system with the antiproliferative signaling process of GnRH receptor, we have evaluated the regulation of Fas ligand expression in GnRH receptor-positive tumors and cloned cell lines known to have substantial GnRH receptors.
|
9467552 |
1998 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We therefore determined whether 1) the GnRH gene is expressed in gonadotroph tumors and normal pituitaries using reverse transcriptase (RT)-PCR; 2) the GnRH receptor gene is co-expressed in gonadotroph tumors; 3) an alternative upstream transcriptional start site on the GnRH gene is utilized; and 4) media from primary cultures of gonadotroph tumors have detectable GnRH immunoreactivity by RIA.
|
8550798 |
1996 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We hypothesized that GnRH nonresponsiveness in these tumors may be due to GnRH receptor (GnRH-Rc) biosynthetic defects.
|
8200967 |
1994 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These findings demonstrate that a mRNA representing the pituitary form of the GnRH receptor (which shows high affinity binding with GnRH) is also expressed in certain normal tissues and in hormone related human tumors and tumor cell lines derived from them.
|
7534732 |
1994 |