|
Malignant neoplasm of breast
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Quantification of GPC-1 level is also pivotal to breast cancer and prostate cancer's patients.
|
30202003 |
2018 |
|
Malignant neoplasm of breast
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Here we show that glypican-1 is strongly expressed in human breast cancers, whereas expression of glypican-1 is low in normal breast tissues.
|
11454708 |
2001 |
|
Malignant neoplasm of breast
|
0.330 |
Biomarker
|
disease |
BEFREE |
α3(V) chains are produced in both basal-like and luminal human breast tumours, and its expression levels are tightly coupled with those of glypican-1 across breast cancer types.
|
28102194 |
2017 |
|
Malignant neoplasm of breast
|
0.330 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Biliary Atresia
|
0.320 |
SusceptibilityMutation
|
disease |
ORPHANET |
Evidence from human and zebrafish that GPC1 is a biliary atresia susceptibility gene.
|
23336978 |
2013 |
|
Biliary Atresia
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Common variants of GPC1 gene were genetically involved in BA risk.
|
27373597 |
2016 |
|
Biliary Atresia
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
We observed a statistically significant increase in deletions at 2q37.3 in patients with BA that resulted in deletion of one copy of GPC1, which encodes glypican 1, a heparan sulfate proteoglycan that regulates Hedgehog signaling and inflammation.
|
23336978 |
2013 |
|
Hypopituitarism
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Hypothyroidism
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Eyelid Xanthoma
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Pancreatic carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A microRNA signature in circulating exosomes is superior to exosomal glypican-1 levels for diagnosing pancreatic cancer.
|
28232049 |
2017 |
|
Pancreatic carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Materials & methods:</b> This work successfully designs and evaluates GPC1-targeted, gemcitabine (GEM)-loaded multifunctional gold nanocarrier for near-infrared fluorescence (NIRF)/MRI and targeted chemotherapy against pancreatic cancer <i>in vitro</i> and <i>in vivo</i>.
|
31414945 |
2019 |
|
Pancreatic carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hence, enumeration of GPC1-positive EVs, solely or in conjunction with GP2, was unable to effectively distinguish between BPD and pancreatic cancer.
|
30800217 |
2019 |
|
Pancreatic carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that miR-96-5p/-182-5p as good markers for PC; miR-96-5p, rather than -182-5p, inhibits GPC1 to suppress proliferation of PC cells.
|
24736782 |
2014 |
|
Pancreatic carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
ORI-GPC1-NP is a promising theranostic platform for the simultaneous diagnosis and effective treatment of pancreatic cancer.
|
30425490 |
2018 |
|
Pancreatic carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
GPC-1 is a type of cell surface heparan sulfate proteoglycan, which is often highly expressed in PC.
|
29750031 |
2018 |
|
Pancreatic carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Glypican-1 is enriched in circulating-exosomes in pancreatic cancer and correlates with tumor burden.
|
29721179 |
2018 |
|
Pancreatic carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
GPC1(+) crExos may serve as a potential non-invasive diagnostic and screening tool to detect early stages of pancreatic cancer to facilitate possible curative surgical therapy.
|
26106858 |
2015 |
|
Pancreatic carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prognostic value of glypican-1 for patients with advanced pancreatic cancer following regional intra-arterial chemotherapy.
|
29963198 |
2018 |
|
Pancreatic carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In view of the importance of members of the TGF-beta family in pancreatic cancer, in the present study, the role of GPC1 in TGF-beta, BMP and activin signaling was analyzed.
|
17016645 |
2006 |
|
Pancreatic carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Glypican-1 (GPC-1) has been recognized as biomarker of pancreatic cancer.
|
30202003 |
2018 |
|
Pancreatic carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
It was reported that glypican-1 is strongly expressed in human pancreatic cancer, and that it may play an essential role in regulating growth-factor responsiveness in pancreatic carcinoma cells.
|
10505759 |
1999 |
|
Bile duct proliferation
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Conjugated hyperbilirubinemia
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Xanthoma
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|