|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of inosine triphosphate pyrophosphatase (rs1127354 and rs6051702) and interferon lambda 4 (IFLN4) (rs12979860) are indicators of anemia and/or sustained virological response (SVR) in patients with chronic hepatitis C on ribavirin/interferon.
|
31359493 |
2020 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Extracellular Matrix Proteins Substantiate IL-28B T allele Effect on Histological Outcome of Chronic Hepatitis C.
|
29893697 |
2019 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The interleukin 28B gene polymorphism, rs8099917, in patients with chronic hepatitis C and response to the treatment with pegylated interferon and ribavirin.
|
30988680 |
2019 |
|
Hepatitis C, Chronic
|
0.200 |
Biomarker
|
disease |
BEFREE |
Interferon lambda 3 (IFN-λ3) is associated with liver fibrosis and inflammation in chronic hepatitis C (CHC) patients, but its impact on carcinogenesis remains controversial and little is known about its effects after viral clearance.
|
30623518 |
2019 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of IL-28B, TBX21 gene polymorphisms and predictors of virological response for chronic hepatitis C.
|
29399747 |
2018 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Reports of the role of host interleukin 28B (IL-28B) genetic variants in liver disease severity in patients with chronic hepatitis C (CHC) have obtained conflicting results.
|
29517696 |
2018 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Recent genomewide association studies in chronic hepatitis C have found a strong influence of genetic polymorphism near the IL28B (IFNL3) gene in response to IFN-α treatment.
|
29369421 |
2018 |
|
Hepatitis C, Chronic
|
0.200 |
Biomarker
|
disease |
BEFREE |
Data Mining and Machine Learning Algorithms Using IL28B Genotype and Biochemical Markers Best Predicted Advanced Liver Fibrosis in Chronic Hepatitis C.
|
29279441 |
2018 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Spontaneous Viral Load Decline and Subsequent Clearance of Chronic Hepatitis C Virus in Postpartum Women Correlates With Favorable Interleukin-28B Gene Allele.
|
28903504 |
2017 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The interdependence and roles of T cell-mediated immune responses and IL28B rs12979860 single-nucleotide polymorphism genotype as predictors of virological response to anti-HCV treatment in patients with chronic hepatitis C were evaluated using nonparametric tests.
|
28440692 |
2017 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Role of serum level and genetic variation of IL-28B in interferon responsiveness and advanced liver disease in chronic hepatitis C patients.
|
28214926 |
2017 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
EGFR rs11506105 and IFNL3 SNPs but not rs8099917 are strongly associated with treatment responses in Iranian patients with chronic hepatitis C.
|
28703131 |
2017 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Moreover, IFNα is used in the therapy of chronic hepatitis C, where a single nucleotide polymorphism of interleukin-28B gene (IL28B) correlates with therapy response.
|
28214980 |
2017 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Role of IL28B genotype in the liver stiffness increase in untreated patients with chronic hepatitis C.
|
28579527 |
2017 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A comparative study of various methods for detection of IL28B rs12979860 in chronic hepatitis C.
|
28281380 |
2017 |
|
Hepatitis C, Chronic
|
0.200 |
Biomarker
|
disease |
BEFREE |
Single nucleotide polymorphisms (SNPs) within DNA region containing interferon lambda 3 (IFNL3) and IFNL4 genes are prognostic factors of treatment response in chronic hepatitis C (CHC).
|
27125837 |
2017 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Distribution of polymorphisms rs12979860, rs8099917 and rs12980275 IL28B in patients with chronic hepatitis C.
|
29264884 |
2017 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
IL28B rs12980275 and HLA rs4273729 genotypes as a powerful predictor factor for rapid, early, and sustained virologic response in patients with chronic hepatitis C.
|
27714501 |
2017 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Impact of PNPLA3 and IFNL3 polymorphisms on hepatic steatosis in Asian patients with chronic hepatitis C.
|
28797039 |
2017 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
No long-term data have been published on the durability of response following pegylated interferon (PegIFN) treatment in children with chronic hepatitis C. This prospective, multicenter, long-term follow-up (LTFU) study aimed to assess long-term durability of sustained virological response (SVR), long-term safety and tolerability, and the association between IL28B genotype and treatment response, in children previously treated with PegIFN alfa-2a ± ribavirin (RBV) in the PEDS-C trial.
|
26284539 |
2016 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Prevalence and clinical implications of IL28B genotypes in Taiwanese patients with chronic hepatitis C.
|
27751759 |
2016 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Type I IFNs (IFNA1, IFNB1), type II (IFNG), type III (IFNL1, IFNL2/3), IFNL4 and ISG hepatic expressions were measured by qPCR from in 65 chronic hepatitis C (CHC) patients whose IFNL4-associated rs368234815 and IFNL3-associated rs12989760 genotype were determined.
|
26020282 |
2016 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
IL28B SNP rs12979860 is the Critical Predictor for Sustained Viral Response in Chinese Children Aged 1 to 6 Years with Chronic Hepatitis C.
|
27877087 |
2016 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Interleukin 28B polymorphisms as predictors of sustained virological response in chronic hepatitis C: systematic review and meta-analysis.
|
25918016 |
2016 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Integrative role of vitamin D related and Interleukin-28B genes polymorphism in predicting treatment outcomes of Chronic Hepatitis C.
|
26911666 |
2016 |