|
Pseudohyperkalemia Cardiff
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study suggests that IL-28B T allele affects the natural course of CHC type 4 and also suggests that carriage of the IL-28B C allele protects from unfavorable clinical outcomes in CHC as coexistence of C allele with T allele reduced cirrhosis severity.
|
29893697 |
2019 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To determine the contribution of IFN-λ3 to hepatocarcinogenesis after HCV clearance, we analyzed IFNL3 genotypes and serial serum IFN-λ3 levels in CHC patients who achieved sustained virologic responses (SVR).
|
30623518 |
2019 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Similarly, GG-GG (PNPLA3-IL28B) is considered a high-risk signature for higher degree of fibrosis.<b>Conclusion:</b> IL28B rs8099917 and PNPLA3 rs738409 introduce genetic signature to identify patients at higher risk for CHC susceptibility and fibrosis progression in CHC G4.
|
31793339 |
2019 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The impact of IL-28B in Asian patients with different viral genotypes remains elusive.We try to elucidate the effect of IL-28B genetic variants in a large Asian cohort with different viral genotypes.The association between the IL-28B rs8099917 genotype and liver fibrosis was investigated in 1288 patients with biopsy-proven CHC.Patients with hepatitis C virus genotype 1 (HCV-1) infection comprised 59.4% of the population.
|
29517696 |
2018 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We compared the role of IL28B SNPs (rs12979860, rs12980275, and rs8099917), IFNL4 ss469415590 and HLA rs4273729 with treatment outcomes in patients with CHC virus.
|
28739427 |
2017 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
IL28B genotype is the predictor for NR in GT-1 CHC patients treated with PegIFN/RBV, while baseline serum level of CCL4 is the only predictor for NR in GT-1 CHC patients with favorable IL28B genotype.
|
29284412 |
2017 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-28B serum level was also significantly higher in healthy group compared with the CHC and LTC groups.
|
28214926 |
2017 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
IL28B genotyping and rs4273729 were performed using the amplification refractory mutation system (ARMS)-PCR and direct sequencing in 190 CHC virus infections, respectively.
|
27714501 |
2017 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this prospective and longitudinal study was to assess the role of different IL28B genotypes in the liver stiffness progression in a cohort of untreated subjects affected by CHC.
|
28579527 |
2017 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
Biomarker
|
disease |
BEFREE |
Single nucleotide polymorphisms (SNPs) within DNA region containing interferon lambda 3 (IFNL3) and IFNL4 genes are prognostic factors of treatment response in chronic hepatitis C (CHC).
|
27125837 |
2017 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of the study is to determine the prevalence of alleles and distribution of IL28B polymorphisms genotypes in the examined group of patients with CHC in Wielkopolska Province.
|
29264884 |
2017 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We developed a triplex high-resolution melting assay for the simultaneous assessment of three genetic polymorphisms related to the response to treatment and development of advanced fibrosis in CHC: IFNL3 rs12979860, ABCB11 rs2287622, and RNF7 rs16851720.
|
28860020 |
2017 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A prospective study was conducted including 474 (250 genotype 1, 224 genotype 2) consecutive chronic hepatitis C (CHC) patients who had completed an anti-HCV therapy course and undergone pre-therapy and 24-week post-therapy assessments of interferon λ3-rs12979860 and HCV RNA/genotypes, anthropometric measurements, metabolic and liver profiles, and complement component 3 (C3), C4, and leptin levels.
|
27870883 |
2016 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Type I IFNs (IFNA1, IFNB1), type II (IFNG), type III (IFNL1, IFNL2/3), IFNL4 and ISG hepatic expressions were measured by qPCR from in 65 chronic hepatitis C (CHC) patients whose IFNL4-associated rs368234815 and IFNL3-associated rs12989760 genotype were determined.
|
26020282 |
2016 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Vitamin D related (VDR rs2228570 and CYP2R1 rs10741657) and IL28B rs12979860 genes polymorphisms accurately assure SVR in naïve CHC G4 patients treated with low cost standard therapy.
|
26911666 |
2016 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We thus investigated the prevalence and clinical implications of IL28B rs8099917 genotypes in CHC patients with different hepatitis C virus (HCV) genotypes and healthy controls.
|
27751759 |
2016 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Compared with HCV viral genotype, ALT level and baseline viral load, IL-28B rs12979860 is more suitable for predicting antiviral efficacy in children with CHC.
|
27877087 |
2016 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
Biomarker
|
disease |
BEFREE |
Individuals with the ancestral IFNλ4 allele capable of producing a fully active IFNλ4 are paradoxically not able to clear HCV in the acute phase and develop chronic hepatitis C (CHC) with more than 90% probability.
|
27641986 |
2016 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Taken together, these data provide evidence of an IFNL3 genotype association with differences in monocyte, T- and NK cell levels in the peripheral blood of patients with CHC.
|
27307212 |
2016 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, there was no observed association of IL28B rs8099917 polymorphism with treatment response in CHC patients (p = 0.264).
|
25703417 |
2015 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was twofold: to study the relationship between IL28B rs12979860 and sustained virological response (SVR) to pegIFN-α/RVB therapy among CHC patients and to detect the rs12979860 polymorphism by high resolution melting curve (HRM) assay as a simple, fast, sensitive, and inexpensive method.
|
25773839 |
2015 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
Biomarker
|
disease |
BEFREE |
The role of interleukin (IL) 28B in the treatment of chronic hepatitis C (CHC) has recently been examined in many studies, while a possible relationship between IL28B and the presence of mixed cryoglobulinemia (MC) remains to be clarified.
|
26060059 |
2015 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although the single-nucleotide polymorphism (SNP) rs12979860 in the IL28B gene is a better predictor of sustained virological response to treatment of chronic hepatitis C (CHC) than other baseline factors, some CHC patients with the favorable C allele cannot achieve a sustained virological response when treated with peginterferon plus ribavirin.
|
25687192 |
2015 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The rate of sustained virologic response (SVR) was higher for the CC genotype of IL28B rs12979860 polymorphisms than for non-CC in both genotype 1 (60.6% vs. 29.4%, P < 0.001) and non-genotype 1 (69.4% vs. 49.1%, P < 0.05) CHC.
|
26339796 |
2015 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
IL28B rs12979860 CC genotype is a significant predictor for SVR and RVR in Chinese Han patients with CHC.
|
25312023 |
2015 |