|
Autoimmune Diseases
|
0.390 |
Biomarker
|
group |
BEFREE |
Our findings provide insight into the molecular basis of type I IFN therapy for CNS autoimmune diseases and identify CXCR3 as a biomarker for effective type I IFN immunotherapy.
|
31291583 |
2019 |
|
Autoimmune Diseases
|
0.390 |
Biomarker
|
group |
BEFREE |
The chemokine receptor CXCR3 and associated CXC chemokines have been extensively investigated in several inflammatory and autoimmune diseases as well as in tumor development.
|
30210493 |
2018 |
|
Autoimmune Diseases
|
0.390 |
Biomarker
|
group |
BEFREE |
The chemokine receptor CXCR3 plays an important role in T cell recruitment in various immune responses and autoimmune diseases.
|
29348563 |
2018 |
|
Autoimmune Diseases
|
0.390 |
Biomarker
|
group |
BEFREE |
CXCL10/IFN-γ-induced protein 10 (IP-10) and its corresponding receptor CXCR3 have long been considered to be involved in the pathophysiology of type 1 T (Th1) cell-orientated autoimmune diseases.
|
28411045 |
2017 |
|
Autoimmune Diseases
|
0.390 |
Biomarker
|
group |
BEFREE |
Therefore, we propose that dual targeting of CXCR3 and CCR6 with a fully humanized BsAb may display a potent interventional approach for the treatment of inflammatory and autoimmune diseases.
|
28873441 |
2017 |
|
Autoimmune Diseases
|
0.390 |
Biomarker
|
group |
BEFREE |
(C-X-C motif) ligand (CXCL)10, an interferon-γ inducible Th1 chemokine, and its receptor, (C-X-C motif) receptor (CXCR)3, have an important role in different autoimmune diseases.
|
24529741 |
2014 |
|
Autoimmune Diseases
|
0.390 |
Biomarker
|
group |
BEFREE |
IP-10 and its receptor, CXCR3, appear to contribute to the pathogenesis of many autoimmune diseases, organ specific (such as type 1 diabetes, Graves' disease and ophthalmopathy), or systemic (such as systemic lupus erythematosus, mixed cryoglobulinemia, Sjogren syndrome, or systemic sclerosis).
|
24977661 |
2014 |
|
Autoimmune Diseases
|
0.390 |
Biomarker
|
group |
BEFREE |
This review focuses on the current understanding of the enigmatic role of CXCR3 and its ligands in CNS inflammatory/autoimmune disorders.
|
16124999 |
2005 |
|
Autoimmune Diseases
|
0.390 |
Biomarker
|
group |
CTD_human |
The CXCR3 chemokine receptor, a member of the CXCR family, has been linked to a pathological role in autoimmune disease, inflammatory disease, allograft rejection, and ischemia.
|
12517959 |
2003 |
|
Autoimmune Diseases
|
0.390 |
AlteredExpression
|
group |
BEFREE |
We have analysed the expression of CXCR3 and CCR5 as Th1-specific chemokine receptors, CCR3 as a marker for Th2 cells, CXCR4 (expressed on unprimed, naive T cells) and CCR2 (known to be involved in autoimmunity) on peripheral blood (PBL) and thyroid-derived lymphocytes (TL) using flow cytometry.
|
11966764 |
2002 |
|
Dermatitis, Atopic
|
0.320 |
Biomarker
|
disease |
BEFREE |
Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis.
|
31631836 |
2019 |
|
Dermatitis, Atopic
|
0.320 |
Biomarker
|
disease |
CTD_human |
Peroxisome proliferator-activated receptor alpha regulates skin inflammation and humoral response in atopic dermatitis.
|
18249437 |
2008 |
|
Dermatitis, Atopic
|
0.320 |
Biomarker
|
disease |
BEFREE |
We observed that CCR4-expressing memory CD4+ T cells in the blood were more increased in AD patients as compared with normal patients, whereas CXCR3-expressing memory CD4+ T cells were present in a lower frequency in AD than seen in normal patients.
|
11037980 |
2000 |
|
Pneumonia
|
0.310 |
Biomarker
|
disease |
CTD_human |
Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression.
|
21625544 |
2011 |
|
Pneumonitis
|
0.310 |
Biomarker
|
disease |
CTD_human |
Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression.
|
21625544 |
2011 |
|
Pneumonia
|
0.310 |
Biomarker
|
disease |
BEFREE |
CXCR3 could be a novel target for the treatment of pulmonary inflammation induced by CS.
|
19026162 |
2008 |
|
Pneumonitis
|
0.310 |
Biomarker
|
disease |
BEFREE |
CXCR3 could be a novel target for the treatment of pulmonary inflammation induced by CS.
|
19026162 |
2008 |
|
Inflammation
|
0.310 |
Biomarker
|
phenotype |
LHGDN |
Effects of chemokines on proliferation and apoptosis of human mesangial cells.
|
15265234 |
2004 |
|
Inflammation
|
0.310 |
Biomarker
|
phenotype |
CTD_human |
Up-regulation of early growth response gene-1 via the CXCR3 receptor induces reactive oxygen species and inhibits Na+/K+-ATPase activity in an immortalized human proximal tubule cell line.
|
12517959 |
2003 |
|
Cerebrovascular accident
|
0.310 |
Biomarker
|
group |
CTD_human |
A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke.
|
12374626 |
2002 |
|
Cerebrovascular accident
|
0.310 |
Biomarker
|
group |
BEFREE |
These data suggest that CXCR3/IP-10 may be a potential novel therapeutic target in focal stroke.
|
10825390 |
2000 |
|
Contact Dermatitis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genes specifically modulated in sensitized skins allow the detection of sensitizers in a reconstructed human skin model. Development of the SENS-IS assay.
|
25724174 |
2015 |
|
Contact hypersensitivity
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Genes specifically modulated in sensitized skins allow the detection of sensitizers in a reconstructed human skin model. Development of the SENS-IS assay.
|
25724174 |
2015 |
|
Alopecia Areata
|
0.300 |
Biomarker
|
disease |
CTD_human |
Increased expression of Cxcr3 and its ligands, Cxcl9 and Cxcl10, during the development of alopecia areata in the mouse.
|
22358057 |
2012 |
|
Hypersensitivity
|
0.300 |
Biomarker
|
group |
CTD_human |
Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression.
|
21625544 |
2011 |