|
Asthma
|
0.170 |
AlteredExpression
|
disease |
BEFREE |
We did not observe an effect of asthma status that would be independent of the genotype and the sex effects in the GSDMA, ZPBP2 and SLC22A5 regions; however, GSDMA and ZPBP2 data were suggestive of interaction between asthma and methylation levels in females and SLC22A5 in males.
|
26671913 |
2016 |
|
Asthma
|
0.170 |
Biomarker
|
disease |
BEFREE |
Gasdermin A (GSDMA) and gasdermin B (GSDMB) have been associated with childhood, and to a lesser extent with adult, asthma in many populations.
|
26886240 |
2016 |
|
Asthma
|
0.170 |
GeneticVariation
|
disease |
BEFREE |
We evidenced a new locus in the 16q12 region (near cylindromatosis turban tumor syndrome gene [CYLD]) and confirmed 4 asthma risk regions: 2q12 (IL-1 receptor-like 1 [IL1RL1]), 6p21 (HLA-DQA1), 9p24 (IL33), and 17q12-q21 (zona pellucida binding protein 2 [ZPBP2]-gasdermin A [GSDMA]).
|
27130862 |
2016 |
|
Asthma
|
0.170 |
GeneticVariation
|
disease |
GWASCAT |
Identification of a new locus at 16q12 associated with time to asthma onset.
|
27130862 |
2016 |
|
Asthma
|
0.170 |
GeneticVariation
|
disease |
BEFREE |
Associations confirmed that the 17q12-17q21.1 locus harbours a genetic determinant for asthma risk in adults and suggest that in addition to the previously known ORMDL3-GSDM locus, CSF3-PSMD3-MED24 also plays a role in asthma pathogenesis.
|
27163155 |
2016 |
|
Asthma
|
0.170 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
|
24388013 |
2014 |
|
Asthma
|
0.170 |
Biomarker
|
disease |
BEFREE |
Among children with asthma, 4 SNPs (in ZPBP2, GSDMB, and GSDMA) were associated with hospital admissions and 8 SNPs with lung function.
|
23622005 |
2013 |
|
Asthma
|
0.170 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study to identify genetic determinants of severe asthma.
|
22561531 |
2012 |
|
Asthma
|
0.170 |
GeneticVariation
|
disease |
BEFREE |
The region including the GSDMA and GSDMB polymorphisms may be associated with asthma susceptibility and intermediate phenotypes of asthma, such as elevated IgE and BHR, in Korean children with asthma.
|
21337730 |
2011 |
|
Asthma
|
0.170 |
GeneticVariation
|
disease |
GWASDB |
Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.
|
21907864 |
2011 |
|
Asthma
|
0.170 |
GeneticVariation
|
disease |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
|
Asthma
|
0.170 |
Biomarker
|
disease |
BEFREE |
Review of previous T1D genome-wide association results revealed that four (human leucocyte antigen (HLA), gasdermin B/ORM1 (Saccharomyces cerevisiae)-like/gasdermin B/, GSDMB/ORMDL3/GSDMA and IL2RB) of ten loci recently reported to be associated with asthma were associated with T1D (p≤0.005).
|
22069270 |
2011 |
|
Asthma
|
0.170 |
GeneticVariation
|
disease |
GWASDB |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
|
Asthma
|
0.170 |
GeneticVariation
|
disease |
GWASCAT |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
|
Childhood asthma
|
0.120 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated the association between GSDMA and GSDMB variants and the incidence of adult and childhood asthma among Jordanians.
|
26886240 |
2016 |
|
Childhood asthma
|
0.120 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations.
|
24241537 |
2014 |
|
Childhood asthma
|
0.120 |
Biomarker
|
disease |
BEFREE |
These results strongly support an important role for the GSDMA and GSDMB in the development of childhood asthma.
|
21337730 |
2011 |
|
Childhood asthma
|
0.120 |
GeneticVariation
|
disease |
GWASDB |
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma.
|
17611496 |
2007 |
|
Eczema
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
White Blood Cell Count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
White Blood Cell Count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analyses of diverse populations improves discovery for complex traits.
|
31217584 |
2019 |
|
Eosinophil count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Systemic Scleroderma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis.
|
28314753 |
2017 |
|
Hay fever
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
|
24388013 |
2014 |
|
White Blood Cell Count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network.
|
22037903 |
2012 |