GPER1, G protein-coupled estrogen receptor 1, 2852

N. diseases: 180; N. variants: 6
Disease: Hypertensive disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.060 AlteredExpression group BEFREE Cardioprotection Induced by Activation of GPER in Ovariectomized Rats With Pulmonary Hypertension. 29790948 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.060 Biomarker group BEFREE Attenuation of Microbiotal Dysbiosis and Hypertension in a CRISPR/Cas9 Gene Ablation Rat Model of GPER1. 30354811 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.060 Biomarker group BEFREE This viewpoint changed recently with the discovery that GPER is associated with aging, particularly that of the cardiovascular system, where the GPER antagonist G36 reduced hypertension and GPER deficiency prevented cardiac fibrosis and vascular dysfunction with age, through the downregulation of Nox1 and as a consequence superoxide production. 28285016 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.060 GeneticVariation group BEFREE We have shown that regulation of GPER function via expression of a hypofunctional GPER genetic variant is an important determinant of blood pressure and risk of hypertension in women. 27213340 2016
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.060 Biomarker group BEFREE The regulation of AVP by raloxifene and GPER may have implications for the treatment of blood hypertension(.). 26200092 2015
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.060 GeneticVariation group BEFREE The common genetic variant, GPER P16L, is hypofunctional and female carriers of this allele have increased blood pressure. 25039431 2014