|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
GPER silencing reduced stemness features of BCSCs as reflected by reduced mammosphere forming capacity in vitro, and tumor growth in vivo with decreased BCSC populations.
|
31340060 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, the effect of a GPR30 inhibitor on tumor growth was determined in vivo using tumor xenograft mouse models.
|
31096733 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
GPR30 positivity was significantly correlated with histological type (p=0.009), tumor diameter (p=0.003), tumor size (p<0.001), lymphovascular infiltration (p=0.005) and UICC stage (p<0.001).
|
31483053 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
On the basis of these studies, we propose that a functional network between HIF-1α, GPER and Notch may integrate tumor microenvironmental cues to induce robust EMT in cancer cells.
|
29996493 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We showed the aberrant expression of AR in mucoepidermoid and oncocytic carcinoma, a strong relation between cytoplasmic ERβ expression and tumor grade, and a strong correlation between nuclear GPR30 expression and disease-free survival (DFS) of SGT patients.
|
29385707 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A correlation between ZNF32/GPER expression and increased tumor incidence and burden was observed in xenograft mouse models.
|
30478301 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In mice bearing MCF-7 or SKBR3 xenografts, tumor growth was inhibited by calycosin, and changes in expression the levels of WDR7-7 and GPR30 in tumor tissues were similar to those in cultured MCF-7 and SKBR3 cells.
|
29096683 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
AXL and MER are two members of the TAM (TYRO3-AXL-MER) family of receptor tyrosine kinases, which, when activated, can regulate tumor cell survival, proliferation, migration and invasion, angiogenesis, and tumor-host interactions.
|
28251492 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We previously demonstrated that treatment of the H295R adrenocortical cancer cell line with the non-steroidal, high-affinity GPER (G protein-coupled estrogen receptor 1) agonist G-1 reduced tumor growth <i>in vitro</i> and <i>in vivo</i> through a GPER independent action.
|
29383185 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This provides support to the tumor suppressor role for GPER1.
|
28286086 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we focus on tumor related GPCRs, such as G protein-coupled receptor 30, the lysophosphatidic acid receptor, angiotensin receptors 1 and 2, the sphingosine 1-phosphate receptors and gastrin releasing peptide receptor.
|
27000991 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Function of G-Protein-Coupled Estrogen Receptor-1 in Reproductive System Tumors.
|
27314054 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
GPR30 was significantly associated with larger tumor size (p = 0.009), increased number of positive lymph nodes (p = 0.04), definite lymph-vascular invasion (LVI) (p = 0.002), peri-nodal invasion (p = 0.02), and the presence of coagulative tumor cell necrosis (p = 0.02).
|
24628533 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Positive GPER staining was identified in 53.8% (14/26) of GCTs and there was no significant relation of GPER with tumor size or lymph node status.
|
25167139 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
GPER functions as a tumor suppressor in triple-negative breast cancer cells.
|
24553912 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We investigated the role of GPER as a potential tumor suppressor in MCF-7 and SK-BR-3 breast cancer cells.
|
24515910 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Together, these results provide the first evidence, to our knowledge, that GPR30 is an androgen-repressed target and G-1 mediates the anti-tumor effect via neutrophil-infiltration-associated necrosis in CRPC.
|
25287069 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Hence, the current study aimed to analyze how GPER may interact with the FSHR/LHCGR system in EOC and whether the prognostic significance of GPER in EOC cases (n=151) may be dependent on the FSHR/LHCGR immunophenotype of the tumor.
|
23951246 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
TAM-R xenografts were established to assess anti-tumor effects of combination therapy with GPR30 antagonist G15 plus 4-hydroxytamoxifen (Tam), using tumor volume measurement and Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL).
|
24289103 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The receptor GPR30 was positively related to tumor size, tumor stage, and lymph node metastasis.
|
22495744 |
2012 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms in GPR30 gene might therefore affect breast cancer susceptibility or tumor characteristics.
|
19744559 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
GPCR-Br was detected in all 4 ER-positive tumors and only 1 of 7 ER-negative tumors.
|
9367686 |
1997 |