|
Primary sclerosing cholangitis
|
0.310 |
SusceptibilityMutation
|
disease |
ORPHANET |
We discovered novel genome-wide significant associations with PSC at 2q37 [rs3749171 at G-protein-coupled receptor 35 (GPR35); P = 3.0 × 10(-9) in the overall study population, combined odds ratio [OR] and 95% confidence interval [CI] of 1.39 (1.24-1.55)] and at 18q21 [rs1452787 at transcription factor 4 (TCF4); P = 2.61 × 10(-8) , OR (95% CI) = 0.75 (0.68-0.83)].
|
22821403 |
2013 |
|
Primary sclerosing cholangitis
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
We discovered novel genome-wide significant associations with PSC at 2q37 [rs3749171 at G-protein-coupled receptor 35 (GPR35); P = 3.0 × 10(-9) in the overall study population, combined odds ratio [OR] and 95% confidence interval [CI] of 1.39 (1.24-1.55)] and at 18q21 [rs1452787 at transcription factor 4 (TCF4); P = 2.61 × 10(-8) , OR (95% CI) = 0.75 (0.68-0.83)].
|
22821403 |
2013 |
|
Inflammatory Bowel Diseases
|
0.130 |
Biomarker
|
group |
BEFREE |
Intriguing examples such as GPR35 for inflammatory bowel disease and CXCR4 for viral infection are used as illustrations of how a systematic approach can aid in the prioritization of interesting drug discovery hypotheses.
|
30285606 |
2018 |
|
Inflammatory Bowel Diseases
|
0.130 |
Biomarker
|
group |
BEFREE |
The orphan receptor G protein-coupled receptor 35 (GPR35) has been associated with a range of diseases, including cancer, inflammatory bowel disease, diabetes, hypertension, and heart failure.
|
29860395 |
2018 |
|
Inflammatory Bowel Diseases
|
0.130 |
Biomarker
|
group |
BEFREE |
In this study, we investigated the contribution of GPR35-mediated signalling to mucosal repair of colonic epithelium in IBD.
|
28648739 |
2017 |
|
Inflammatory Bowel Diseases
|
0.130 |
GeneticVariation
|
group |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
|
Inflammatory Bowel Diseases
|
0.130 |
GeneticVariation
|
group |
GWASCAT |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
Inflammatory Bowel Diseases
|
0.130 |
GeneticVariation
|
group |
GWASDB |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
Fibrosis, Liver
|
0.110 |
Biomarker
|
disease |
BEFREE |
Therefore, these results showed anti-fibrotic effects of lodoxamide in mice and raise concerns how lodoxamide protects against liver fibrosis <i>in vivo</i> and whether GPR35 is involved in the action.
|
31189299 |
2019 |
|
Ulcerative Colitis
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Enhanced Contribution of HLA in Pediatric Onset Ulcerative Colitis.
|
29562276 |
2018 |
|
Congestive heart failure
|
0.110 |
Biomarker
|
disease |
BEFREE |
The orphan receptor G protein-coupled receptor 35 (GPR35) has been associated with a range of diseases, including cancer, inflammatory bowel disease, diabetes, hypertension, and heart failure.
|
29860395 |
2018 |
|
Ulcerative Colitis
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Crohn Disease
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Ulcerative Colitis
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
|
Ulcerative Colitis
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
|
Crohn Disease
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
|
Crohn Disease
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
We confirmed 6 previously reported loci in Caucasian: GPR35 at 2q37 (rs3749172; P = 5.30 × 10, odds ratio [OR] = 1.45), ZNF365 at 10q21 (rs224143; P = 2.20 × 10, OR = 1.38), ZMIZ1 at 10q22 (rs1250569; P = 3.05 × 10, OR = 1.30), NKX2-3 at 10q24 (rs4409764; P = 7.93 × 10, OR = 1.32), PTPN2 at 18p11 (rs514000; P = 9.00 × 10, OR = 1.33), and USP25 at 21q11 (rs2823256; P = 2.49 × 10, OR = 1.35), bringing the number of known CD loci (including 3 in the HLA) in Koreans to 15.
|
25489960 |
2015 |
|
Crohn Disease
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans.
|
25489960 |
2015 |
|
Ulcerative Colitis
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4.
|
22821403 |
2013 |
|
Ulcerative Colitis
|
0.110 |
Biomarker
|
disease |
HPO |
|
|
|
|
Congestive heart failure
|
0.110 |
Biomarker
|
disease |
HPO |
|
|
|
|
Fibrosis, Liver
|
0.110 |
Biomarker
|
disease |
HPO |
|
|
|
|
Eosinophil count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Cholangitis, Sclerosing
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Psoriasis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |