|
Childhood Acute Lymphoblastic Leukemia
|
0.340 |
Biomarker
|
disease |
BEFREE |
Genomic and transcriptional landscape of P2RY8-CRLF2-positive childhood acute lymphoblastic leukemia.
|
27899802 |
2017 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
As controversy exists regarding the prognostic significance of genomic rearrangements of CRLF2 in pediatric B-precursor acute lymphoblastic leukemia (ALL) classified as standard/intermediate-risk (SR) or high-risk (HR), we assessed the prognostic significance of CRLF2 mRNA expression, CRLF2 genomic lesions (IGH@-CRLF2, P2RY8-CRLF2, CRLF2 F232C), deletion/mutation in genes frequently associated with high CRLF2 expression (IKZF1, JAK, IL7R), and minimal residual disease (MRD) in 1061 pediatric ALL patients (499 HR and 562 SR) on COG Trials P9905/P9906.
|
22368272 |
2012 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
To investigate whether and to what extent different clone sizes influence disease and relapse development, we quantified the genomic P2RY8-CRLF2 fusion product and correlated it with the corresponding CRLF2 expression levels in patients enrolled in the BFM-ALL 2000 protocol in Austria.
|
23091296 |
2012 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.340 |
Biomarker
|
disease |
CTD_human |
We identified the P2RY8-CRLF2 fusion in 7% of individuals with B-progenitor ALL and 53% of individuals with ALL associated with Down syndrome.
|
19838194 |
2009 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
We identified the P2RY8-CRLF2 fusion in 7% of individuals with B-progenitor ALL and 53% of individuals with ALL associated with Down syndrome.
|
19838194 |
2009 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.320 |
Biomarker
|
disease |
BEFREE |
Children with P2RY8-CRLF2-positive acute lymphoblastic leukemia have an increased relapse risk.
|
27899802 |
2017 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
Poor prognosis for P2RY8-CRLF2 fusion but not for CRLF2 over-expression in children with intermediate risk B-cell precursor acute lymphoblastic leukemia.
|
22484421 |
2012 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.320 |
Biomarker
|
disease |
CTD_human |
Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia.
|
19838194 |
2009 |
|
L2 Acute Lymphoblastic Leukemia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia.
|
19838194 |
2009 |
|
Acute lymphocytic leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Children with P2RY8-CRLF2-positive acute lymphoblastic leukemia have an increased relapse risk.
|
27899802 |
2017 |
|
Acute lymphocytic leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
As controversy exists regarding the prognostic significance of genomic rearrangements of CRLF2 in pediatric B-precursor acute lymphoblastic leukemia (ALL) classified as standard/intermediate-risk (SR) or high-risk (HR), we assessed the prognostic significance of CRLF2 mRNA expression, CRLF2 genomic lesions (IGH@-CRLF2, P2RY8-CRLF2, CRLF2 F232C), deletion/mutation in genes frequently associated with high CRLF2 expression (IKZF1, JAK, IL7R), and minimal residual disease (MRD) in 1061 pediatric ALL patients (499 HR and 562 SR) on COG Trials P9905/P9906.
|
22368272 |
2012 |
|
Acute lymphocytic leukemia
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Poor prognosis for P2RY8-CRLF2 fusion but not for CRLF2 over-expression in children with intermediate risk B-cell precursor acute lymphoblastic leukemia.
|
22484421 |
2012 |
|
Acute lymphocytic leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We identified the P2RY8-CRLF2 fusion in 7% of individuals with B-progenitor ALL and 53% of individuals with ALL associated with Down syndrome.
|
19838194 |
2009 |
|
Precursor B-cell lymphoblastic leukemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
In addition, we use Clinker to explore multiple fusion transcripts with novel breakpoints within the P2RY8-CRLF2 fusion gene in B-cell acute lymphoblastic leukemia.
|
29982439 |
2018 |
|
Precursor B-cell lymphoblastic leukemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The results showed that CRLF2 overexpression and P2RY8-CRLF2 were associated with a poor outcome in unselected B-ALL.
|
27637012 |
2017 |
|
Precursor B-cell lymphoblastic leukemia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Presence of the P2RY8-CRLF2 rearrangement is associated with a poor prognosis in non-high-risk precursor B-cell acute lymphoblastic leukemia in children treated according to the ALL-BFM 2000 protocol.
|
20378752 |
2010 |
|
Malignant Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
As the P2RY8 locus is modified in several other types of cancer in addition to GCB-DLBCL and Burkitt lymphoma, we speculate that GGG might have organizing and growth-regulatory roles in multiple human tissues.
|
30842656 |
2019 |
|
Primary malignant neoplasm
|
0.020 |
GeneticVariation
|
group |
BEFREE |
As the P2RY8 locus is modified in several other types of cancer in addition to GCB-DLBCL and Burkitt lymphoma, we speculate that GGG might have organizing and growth-regulatory roles in multiple human tissues.
|
30842656 |
2019 |
|
Neoplasm, Residual
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Lower relapse-free survival at 7 years (RFS) was associated with IKZF1 intragenic deletions (P < 0·0001); P2RY8-CRLF2 gene fusion (P < 0·0004); Day 33 MRD>5 × 10<sup>-5</sup> (P < 0·0001) and High National Cancer Institute (NCI) risk (P < 0·0001).
|
29194562 |
2018 |
|
Malignant Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
The incomplete phenocopy of Gα13- and S1PR2 deficiency led us to discover that P2RY8, an orphan receptor that is mutated in GCB-DLBCL and another germinal centre B-cell-derived malignancy, Burkitt's lymphoma, also represses germinal centre B-cell growth and promotes confinement via Gα13.
|
25274307 |
2014 |
|
Primary malignant neoplasm
|
0.020 |
GeneticVariation
|
group |
BEFREE |
The incomplete phenocopy of Gα13- and S1PR2 deficiency led us to discover that P2RY8, an orphan receptor that is mutated in GCB-DLBCL and another germinal centre B-cell-derived malignancy, Burkitt's lymphoma, also represses germinal centre B-cell growth and promotes confinement via Gα13.
|
25274307 |
2014 |
|
Down Syndrome
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We analyzed the prognostic impact of cytokine receptor-like factor 2 (CRLF2) over-expression and P2RY8-CRLF2 fusion in 464 BCP-ALL patients (not affected by Down syndrome and BCR-ABL negative) enrolled in the AIEOP-BFM ALL2000 study in Italy.
|
22484421 |
2012 |
|
Neoplasm, Residual
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
As controversy exists regarding the prognostic significance of genomic rearrangements of CRLF2 in pediatric B-precursor acute lymphoblastic leukemia (ALL) classified as standard/intermediate-risk (SR) or high-risk (HR), we assessed the prognostic significance of CRLF2 mRNA expression, CRLF2 genomic lesions (IGH@-CRLF2, P2RY8-CRLF2, CRLF2 F232C), deletion/mutation in genes frequently associated with high CRLF2 expression (IKZF1, JAK, IL7R), and minimal residual disease (MRD) in 1061 pediatric ALL patients (499 HR and 562 SR) on COG Trials P9905/P9906.
|
22368272 |
2012 |
|
Adult Acute Lymphocytic Leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
As controversy exists regarding the prognostic significance of genomic rearrangements of CRLF2 in pediatric B-precursor acute lymphoblastic leukemia (ALL) classified as standard/intermediate-risk (SR) or high-risk (HR), we assessed the prognostic significance of CRLF2 mRNA expression, CRLF2 genomic lesions (IGH@-CRLF2, P2RY8-CRLF2, CRLF2 F232C), deletion/mutation in genes frequently associated with high CRLF2 expression (IKZF1, JAK, IL7R), and minimal residual disease (MRD) in 1061 pediatric ALL patients (499 HR and 562 SR) on COG Trials P9905/P9906.
|
22368272 |
2012 |
|
Complete Trisomy 21 Syndrome
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We analyzed the prognostic impact of cytokine receptor-like factor 2 (CRLF2) over-expression and P2RY8-CRLF2 fusion in 464 BCP-ALL patients (not affected by Down syndrome and BCR-ABL negative) enrolled in the AIEOP-BFM ALL2000 study in Italy.
|
22484421 |
2012 |