|
Red cell distribution width determination
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
RDW - Red blood cell distribution width result
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Furthermore, the EGFR kinase inhibitor erlotinib blocked sphere formation of TGS-01 cells in culture and inhibited tumor formation in vivo.
|
29193056 |
2018 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
In the present study, hTRM9L was shown to prevent tumor growth and promote apoptosis by regulating LIN9, which is associated with the pRB and p53 signaling pathways.
|
29085442 |
2017 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Our study links hTRM9L and tRNA modifications to inhibition of tumour growth via LIN9 and HIF1-α-dependent mechanisms.
|
23381944 |
2013 |
|
Malignant neoplasm of breast
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The data showed that high LIN9 expression in breast cancer patients receiving chemotherapy was related to poor overall survival (OS).
|
31420851 |
2020 |
|
Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The data showed that high LIN9 expression in breast cancer patients receiving chemotherapy was related to poor overall survival (OS).
|
31420851 |
2020 |
|
Tuberculosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
For the first time, potential TB-associated promoting effects were identified for the decreased expression levels of lnc-AC145676.2.1-6 and lnc-TGS-1, while lnc-TGS1-1 and its variant rs4737420 may be predictive indicators of anti-TB drug-induced adverse drug reactions.
|
31028876 |
2019 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Elevated expression of MYBL2, LIN9, LIN52 and FOXM1 were related to the higher TRA of B-Myb in HCC.
|
29274707 |
2018 |
|
Tuberculosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
TGS-TB: Total Genotyping Solution for Mycobacterium tuberculosis Using Short-Read Whole-Genome Sequencing.
|
26565975 |
2015 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated whether putative functional variants in genes regulating MYBL2 (E2F1, E2F3 and E2F4) or in genes, which are regulated by MYBL2 (BCL2, BIRC5, COL1A1, COL1A2, COL5A2, ERBB2, CLU, LIN9 and TOP2A) affect breast cancer (BC) susceptibility and clinical outcome.
|
22037783 |
2012 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated whether putative functional variants in genes regulating MYBL2 (E2F1, E2F3 and E2F4) or in genes, which are regulated by MYBL2 (BCL2, BIRC5, COL1A1, COL1A2, COL5A2, ERBB2, CLU, LIN9 and TOP2A) affect breast cancer (BC) susceptibility and clinical outcome.
|
22037783 |
2012 |
|
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Activation of v-Myb avian myeloblastosis viral oncogene homolog-like2 (MYBL2)-LIN9 complex contributes to human hepatocarcinogenesis and identifies a subset of hepatocellular carcinoma with mutant p53.
|
21480327 |
2011 |
|
Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
To search for novel fusion genes, we obtained RNA-seq data from TGS-01 human glioma-initiating cells, and identified a novel fusion gene (HMGA2-EGFR), encoding a protein comprising the N-terminal region of the high-mobility group AT-hook protein 2 (HMGA2) fused to the C-terminal region of epidermal growth factor receptor (EGFR), which retained the transmembrane and kinase domains of the EGFR.
|
29193056 |
2018 |
|
Malignant Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Together, these results provide a mechanism for cancer selectivity of BETi that extends beyond modulation of SE-associated genes and suggest that cancers dependent upon LIN9 overexpression may be particularly vulnerable to BETi.<i>Cancer Res; 77(19); 5395-408.©2017 AACR</i>.
|
28807940 |
2017 |
|
B-Cell Lymphomas
|
0.010 |
Biomarker
|
group |
BEFREE |
The lentiviruses were subsequently compounded and transduced into HO8910PM cells. hTRM9L, LIN9 and B-cell lymphoma 2 (Bcl-2)/Bcl-2 associated X protein (Bax) expression levels were examined by PCR and western blot analysis.
|
29085442 |
2017 |
|
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Together, these results provide a mechanism for cancer selectivity of BETi that extends beyond modulation of SE-associated genes and suggest that cancers dependent upon LIN9 overexpression may be particularly vulnerable to BETi.<i>Cancer Res; 77(19); 5395-408.©2017 AACR</i>.
|
28807940 |
2017 |
|
Triple Negative Breast Neoplasms
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mitotic Vulnerability in Triple-Negative Breast Cancer Associated with LIN9 Is Targetable with BET Inhibitors.
|
28807940 |
2017 |
|
Triple-Negative Breast Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mitotic Vulnerability in Triple-Negative Breast Cancer Associated with LIN9 Is Targetable with BET Inhibitors.
|
28807940 |
2017 |
|
nervous system disorder
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The advent of next generation sequencing (NGS, which consists of massively parallel sequencing to perform TGS (total genome sequencing) or WES (whole exome sequencing)) has abundantly discovered many causative mutations in patients with pediatric neurological disease.
|
27036065 |
2016 |
|
Malignant neoplasm of urinary bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, Kaplan-Meier analysis showed that low TGS2 expression is significantly correlated with reduced overall survival in patients with bladder cancer.
|
25323766 |
2015 |
|
Bladder Neoplasm
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
High UHRF1 expression of correlated with aberrant TGS2 promoter methylation in bladder tumors, which results in the loss of TGS2 expression, as confirmed by demethylation analysis in cell lines.
|
25323766 |
2015 |
|
Carcinoma of bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, Kaplan-Meier analysis showed that low TGS2 expression is significantly correlated with reduced overall survival in patients with bladder cancer.
|
25323766 |
2015 |
|
myeloblastosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Activation of v-Myb avian myeloblastosis viral oncogene homolog-like2 (MYBL2)-LIN9 complex contributes to human hepatocarcinogenesis and identifies a subset of hepatocellular carcinoma with mutant p53.
|
21480327 |
2011 |
|
Hepatocarcinogenesis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Activation of v-Myb avian myeloblastosis viral oncogene homolog-like2 (MYBL2)-LIN9 complex contributes to human hepatocarcinogenesis and identifies a subset of hepatocellular carcinoma with mutant p53.
|
21480327 |
2011 |