Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Variants in the ANK3 gene encoding ankyrin-G are associated with neurodevelopmental disorders, including intellectual disability, autism, schizophrenia, and bipolar disorder.
|
31813652 |
2020 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies 30 loci associated with bipolar disorder.
|
31043756 |
2019 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study identifies 30 loci associated with bipolar disorder.
|
31043756 |
2019 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Finally, we identified the ANK3 W1989R variant in a family with bipolar disorder, suggesting a potential role of this variant in disease.
|
30504823 |
2018 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Elevated expression of a minor isoform of ANK3 is a risk factor for bipolar disorder.
|
30297702 |
2018 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
A protein-protein interaction network was generated using STRING to probe the relationship between ANK3 and CACNA1C interactors and their associations with BD.
|
29684488 |
2018 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder.
|
28072414 |
2017 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The goal of the present study was to evaluate the association of ANK3 variants with BD in the Korean population.
|
28079488 |
2017 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Effects of ANK3 variation on gray and white matter in bipolar disorder.
|
27240527 |
2017 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Lithium reverses behavioral and axonal transport-related changes associated with ANK3 bipolar disorder gene disruption.
|
28109561 |
2017 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
ANK3 and ZNF804A polymorphisms have shown the most consistent results, with the risk alleles showing abnormal white matter integrity in patients with BD.
|
28648753 |
2017 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
These mice exhibit an Ank3 gene dosage-dependent phenotype including behavior changes modeling bipolar disorder, epilepsy and sudden death.
|
27956739 |
2017 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In the present meta-analysis, we aimed to establish whether ANK3 single nucleotide polymorphisms (SNPs) confer increased risk for BD.
|
29068871 |
2017 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A polymorphism (rs10994336) within the ANK3 gene has been associated with BD in at least three genome-wide association studies of BD [McGuffin et al., 2003; Kieseppä, 2004; Edvardsen et al., 2008].
|
27177275 |
2016 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The ankyrin 3 genotype may be associated with pathogenesis of age-related neurodegeneration, and, in part, of BD.
|
27488254 |
2016 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The splice site single nucleotide polymorphism (rs41283526) is located in an alternatively spliced exon of ANK3 and has a strong and significant protective effect against bipolar disorder (odds ratio = .31) and schizophrenia (odds ratio = .21).
|
26682468 |
2016 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Most GWAS risk variations were reported to affect neuroimaging phenotypes implicated in SZ/BD: white-matter integrity (ANK3 and ZNF804A), volume (CACNA1C and ZNF804A) and density (ZNF804A); grey-matter (CACNA1C, NRGN, TCF4 and ZNF804A) and ventricular (TCF4) volume; cortical folding (NCAN) and thickness (ZNF804A); regional activation during executive tasks (ANK3, CACNA1C, DGKH, NRGN and ZNF804A) and functional connectivity during executive tasks (CACNA1C and ZNF804A), facial affect recognition (CACNA1C and ZNF804A) and theory-of-mind (ZNF804A); but inconsistencies and non-replications also exist.
|
25858580 |
2015 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This study provides new insights on the neurogenetic correlates of allelic variation at different genome-wide supported BD-risk associated ANK3 loci that support their involvement in BD and highlight the modulatory influence of increased background genetic risk for BD.
|
25711502 |
2015 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Abnormalities in the reactivity of intracellular signal pathways to stimulation and the ANK3 genotype may be associated with pathogenesis of BD.
|
25311363 |
2015 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Based on the hypothesis that both schizophrenia (SZ) and BD may share some common genetic risk factors, we investigated the association of CACNA1C and ANK3 with SZ using meta-analytic techniques, combining all published data up to April 2015.
|
26227746 |
2015 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
PSYGENET |
This study provides new insights on the neurogenetic correlates of allelic variation at different genome-wide supported BD-risk associated ANK3 loci that support their involvement in BD and highlight the modulatory influence of increased background genetic risk for BD.
|
25711502 |
2015 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Of the predicted miR-34a targets, we validated the BD risk genes ankyrin-3 (ANK3) and voltage-dependent L-type calcium channel subunit beta-3 (CACNB3) as direct miR-34a targets.
|
25623948 |
2015 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genetic association of LMAN2L gene in schizophrenia and bipolar disorder and its interaction with ANK3 gene polymorphism.
|
24914473 |
2014 |
Bipolar Disorder
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
ANK3 gene expression in bipolar disorder and schizophrenia.
|
24809399 |
2014 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study reveals two new risk loci for bipolar disorder.
|
24618891 |
2014 |