Our investigation revealed that IS and PD have in common five shared genes: <i>GPX7, LBH, ZCCHC10, DENND2A</i>, and <i>NUDT14</i>, which pass gene-based tests.
Reverse transcription polymerase chain reaction (PCR) and real-time quantitative PCR showed that expression of the detoxification enzymes-- cytochrome P450 family 1 subfamily A member 2, paraoxonase 1, alcohol dehydrogenase 1, UDP glucuronosyltransferase family 2 member A1 complex locus, aldehyde oxidase homolog 2, and aldehyde glutathione peroxidase 6--was significantly increased in the olfactory bulb (OB) of the PD control group, but these enzymes were normalized in the EE group.