DisGeNET - a database of gene-disease associations

GRB7, growth factor receptor bound protein 7, 2886

N. diseases: 71; N. variants: 1

Disease: Malignant neoplasm of stomach ×

Source: ALL

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Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Disease

Score _gda

Association Type

Type

Original DB

Sentence supporting the association

PMID

PMID Year

CUI:	C0024623
Disease:	Malignant neoplasm of stomach

Malignant neoplasm of stomach

0.030

GeneticVariation

disease

BEFREE

PPP1R1B-STARD3-TCAP-PNMT-PERLD1-ERBB2-MGC14832-GRB7 locus at human chromosome 17q12 is frequently amplified in human gastric cancer and breast cancer.

15010812

2004

CUI:	C0024623
Disease:	Malignant neoplasm of stomach

Malignant neoplasm of stomach

0.030

Biomarker

disease

BEFREE

PPP1R1B, STARD3, MGC9753, ERBB2 and GRB7 genes are co-amplified in several cases of gastric cancer.

12739007

2003

CUI:	C0024623
Disease:	Malignant neoplasm of stomach

Malignant neoplasm of stomach

0.030

AlteredExpression

disease

BEFREE

Grb7 is overexpressed in breast, oesophageal and gastric cancers, and may contribute to the invasive potential of cancer cells.

14585167

2003