Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2678051
Disease: MENTAL RETARDATION, X-LINKED 94 (disorder)
MENTAL RETARDATION, X-LINKED 94 (disorder) 		0.700 GeneticVariation disease UNIPROT Mutations in ionotropic AMPA receptor 3 alter channel properties and are associated with moderate cognitive impairment in humans. 17989220 2007
CUI: C2678051
Disease: MENTAL RETARDATION, X-LINKED 94 (disorder)
MENTAL RETARDATION, X-LINKED 94 (disorder) 		0.700 Biomarker disease GENOMICS_ENGLAND Mutations in ionotropic AMPA receptor 3 alter channel properties and are associated with moderate cognitive impairment in humans. 17989220 2007
CUI: C2678051
Disease: MENTAL RETARDATION, X-LINKED 94 (disorder)
MENTAL RETARDATION, X-LINKED 94 (disorder) 		0.700 GermlineCausalMutation disease ORPHANET Mutations in ionotropic AMPA receptor 3 alter channel properties and are associated with moderate cognitive impairment in humans. 17989220 2007
CUI: C2678051
Disease: MENTAL RETARDATION, X-LINKED 94 (disorder)
MENTAL RETARDATION, X-LINKED 94 (disorder) 		0.700 GeneticVariation disease CLINVAR
CUI: C2678051
Disease: MENTAL RETARDATION, X-LINKED 94 (disorder)
MENTAL RETARDATION, X-LINKED 94 (disorder) 		0.700 CausalMutation disease CLINVAR
CUI: C2678051
Disease: MENTAL RETARDATION, X-LINKED 94 (disorder)
MENTAL RETARDATION, X-LINKED 94 (disorder) 		0.700 Biomarker disease CTD_human
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.320 AlteredExpression disease BEFREE Gender, pregnancy or depression during pregnancy altered the expression of GluA3, GluK4, GluN2D, GluN3B and GluD1 iGlu subunit mRNAs. 28284346 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.320 AlteredExpression disease BEFREE Gender, pregnancy or depression during pregnancy altered the expression of GluA3, GluK4, GluN2D, GluN3B and GluD1 iGlu subunit mRNAs. 28284346 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 PosttranslationalModification disease BEFREE The methylation of GRIA3 highly increased the risk of schizophrenia, but non-significant (OR=2.3, 95% CI; 0.51-10.42). 23149219 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 Biomarker disease PSYGENET To the best of our knowledge, this is the first evidence showing that the promoter methylation of the GMR2 and GMR5 genes greatly decreased the risk of schizophrenia, and the expression level of the GRM2, GRM5, and GRIA3 genes increased significantly in patients in comparison to healthy controls. 23149219 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.320 GeneticVariation disease BEFREE We examined whether polymorphisms in the GRIK2, GRIA3 and GRIA1 genes were associated with selective serotonin reuptake inhibitor (SSRI)-associated sexual dysfunction in 114 participants treated for depression. 22534499 2012
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.320 Biomarker disease PSYGENET We examined whether polymorphisms in the GRIK2, GRIA3 and GRIA1 genes were associated with selective serotonin reuptake inhibitor (SSRI)-associated sexual dysfunction in 114 participants treated for depression. 22534499 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.320 Biomarker disease PSYGENET We examined whether polymorphisms in the GRIK2, GRIA3 and GRIA1 genes were associated with selective serotonin reuptake inhibitor (SSRI)-associated sexual dysfunction in 114 participants treated for depression. 22534499 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.320 GeneticVariation disease BEFREE We examined whether polymorphisms in the GRIK2, GRIA3 and GRIA1 genes were associated with selective serotonin reuptake inhibitor (SSRI)-associated sexual dysfunction in 114 participants treated for depression. 22534499 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.320 Biomarker disease PSYGENET The GRIA3 polymorphism that was previously found to be associated with depressive disorder in women showed an association with sleep duration in healthy women. 21966062 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.320 GeneticVariation disease BEFREE The genes most consistently associated with BD in the genetic studies we reviewed were GSK3beta , GRK3, 5-HTTLPR, GRIN3, COMT, and GLUR3. 20226637 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.320 Biomarker disease PSYGENET The genes most consistently associated with BD in the genetic studies we reviewed were GSK3beta , GRK3, 5-HTTLPR, GRIN3, COMT, and GLUR3. 20226637 2010
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.320 Biomarker disease PSYGENET We also found suggestive associations in women for GAD1, GRIA3, and BDNF with depression accompanied by fatigue, and for CRHR1 with depression accompanied by early morning awakenings. 19548263 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.320 Biomarker disease PSYGENET We also found suggestive associations in women for GAD1, GRIA3, and BDNF with depression accompanied by fatigue, and for CRHR1 with depression accompanied by early morning awakenings. 19548263 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 Biomarker disease BEFREE We conclude that, of the three AMPA genes analyzed here, only GRIA3 seems to be involved in the pathogenesis of schizophrenia, but only in females. 18163426 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 Biomarker disease LHGDN We conclude that, of the three AMPA genes analyzed here, only GRIA3 seems to be involved in the pathogenesis of schizophrenia, but only in females. 18163426 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 Biomarker disease PSYGENET We conclude that, of the three AMPA genes analyzed here, only GRIA3 seems to be involved in the pathogenesis of schizophrenia, but only in females. 18163426 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.320 Biomarker disease PSYGENET In the perirhinal cortex we detected decreased expression of GluR5 in all three diagnoses, of GluR1, GluR3, NR2B in both BD and MDD, and decreased NR1 and NR2A in BD and MDD, respectively. 17299517 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.320 Biomarker disease PSYGENET In particular, the Ca(2+) permeable glutamate receptor subunit 3 (GluR3) has been implicated in several neurologic conditions such as bipolar disorder and epilepsy. 15264227 2004
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.320 Biomarker disease PSYGENET No gene contained in this interval has been so far associated with nonsyndromic mental retardation, except for GRIA3, disrupted by a balanced translocation in a female patient with bipolar affective disorder and mental retardation. 15526294 2004