|
Behavior Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
We review specific features of the most common sleep disorders in PD, including insomnia, excessive daytime sleepiness, sleep-disordered breathing, restless legs syndrome, circadian rhythm disorders and REM sleep behavior disorders.
|
31733692 |
2020 |
|
Behavior Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
While on the other hand control of motor activity during sleep is impaired, with subsequent manifestation of parasomnias (mainly REM sleep behavior disorders, but also, albeit more rarely, sleepwalking, and overlap parasomnia).
|
31234200 |
2020 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
The observed effect of REM sleep during daytime napping may not represent the effect of nighttime REM sleep in depression.
|
31550615 |
2020 |
|
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The observed effect of REM sleep during daytime napping may not represent the effect of nighttime REM sleep in depression.
|
31550615 |
2020 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The observed effect of REM sleep during daytime napping may not represent the effect of nighttime REM sleep in depression.
|
31550615 |
2020 |
|
Sleep Apnea, Obstructive
|
0.100 |
Biomarker
|
disease |
BEFREE |
For 6-12-year-old subjects, after adjustment for age and FSIQ, both %REM and OSA were associated with lower score of the subtest of language domain, WPPSI-R Vocabulary, while %REM was also associated with lower score of VABS-II Communication - Expressive.
|
31378642 |
2020 |
|
REM Sleep Behavior Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
This case showed typical RBD symptoms with REM sleep without atonia on polysomnography.
|
31777313 |
2020 |
|
Behavior Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
The most common sleep disorders that can result in injurious or violent behaviors include REM sleep behavioral disorder, sleepwalking, comorbid parasomnias, sleep-related dissociative disorder, and obstructive sleep apnea.
|
30736884 |
2019 |
|
Behavior Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Loss of DA-ergic neurons and disturbed REM sleep (REMS) are associated with Parkinson's disease, depression and REMS behavior disorder.
|
31442548 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Additionally, high selectivity was also observed between cancer and normal cells (23.35 μM against GES-1).
|
30388465 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In in vitro anticancer activity, most derivatives showed considerable cytotoxic activity against four cancer cell lines (RPMI-8226, A549, MDA-MB-231, and HepG2 cancer cells) and showed low toxicity against human gastric mucosal cells (GES-1).
|
30689273 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The MT1‑MMP expression level in cancer‑derived cell line AGS cells was also significantly increased compared with that in non‑cancer‑derived GES‑1 cells.
|
30720114 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To investigate the anticancer effects of stigmasterol on the human gastric cancer cell line SNU-1, GES-1 normal cell line and to also investigate the effects on cancer cell migration, cell cycle phase distribution, apoptosis and JAK/STAT signalling pathway.
|
30570868 |
2019 |
|
Cataplexy
|
0.100 |
Biomarker
|
disease |
BEFREE |
<i>Orexin/Arch</i> mice also had increased REM sleep under baseline conditions but did not exhibit cataplexy, a sudden loss of muscle tone during wakefulness characteristic of NT1.
|
31628177 |
2019 |
|
Cataplexy
|
0.100 |
Biomarker
|
disease |
BEFREE |
To validate polysomnographic markers (sleep latency and sleep-onset REM periods [SOREMPs] at the Multiple Sleep Latency Test [MSLT] and nocturnal polysomnography [PSG]) for pediatric narcolepsy type 1 (NT1) against CSF hypocretin-1 (hcrt-1) deficiency and presence of cataplexy, as no criteria are currently validated in children.
|
31405906 |
2019 |
|
Cataplexy
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, these results demonstrate that DORA's potently increase NREM and REM sleep in mice via blockade of orexin signaling, and higher doses can cause cataplexy when co-administered with a likely rewarding stimulus.
|
31830270 |
2019 |
|
Cataplexy
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we tested the long-standing hypothesis that muscle paralysis during cataplexy is caused by recruitment of the brainstem circuit that induces muscle paralysis during REM sleep.
|
31679942 |
2019 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Loss of DA-ergic neurons and disturbed REM sleep (REMS) are associated with Parkinson's disease, depression and REMS behavior disorder.
|
31442548 |
2019 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Under this protocol, the thermoregulatory and autonomic activation led to a tonic increase in waking and to a reciprocal depression in sleep occurrence, which was more evident for REM sleep.
|
30887077 |
2019 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
We explored the associations between REM sleep fragmentation, depressive symptoms, and a polygenic risk score (PRS) for depression among adolescents.
|
30448760 |
2019 |
|
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Under this protocol, the thermoregulatory and autonomic activation led to a tonic increase in waking and to a reciprocal depression in sleep occurrence, which was more evident for REM sleep.
|
30887077 |
2019 |
|
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
We explored the associations between REM sleep fragmentation, depressive symptoms, and a polygenic risk score (PRS) for depression among adolescents.
|
30448760 |
2019 |
|
Depressive disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Loss of DA-ergic neurons and disturbed REM sleep (REMS) are associated with Parkinson's disease, depression and REMS behavior disorder.
|
31442548 |
2019 |
|
Malignant neoplasm of stomach
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we demonstrated that the LEMD1 expression level was increased in GC tissues and cells compared with normal tissues and GES-1.
|
31021450 |
2019 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Loss of DA-ergic neurons and disturbed REM sleep (REMS) are associated with Parkinson's disease, depression and REMS behavior disorder.
|
31442548 |
2019 |