|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data do not support the hypothesis that progranulin is an important link between obesity, insulin resistance, and MetS in childhood.
|
31469472 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently, PGRN has been found to be an adipokine associated with diet-induced obesity and insulin resistance.
|
31237618 |
2019 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Serum progranulin concentrations and subcutaneous (sc) as well as visceral (vis) adipose tissue (AT) progranulin expression were quantified in a large cohort of patients with obesity undergoing bariatric surgery (BS) (n = 153) or a low-calorie diet (LCD) (n = 121).
|
31102282 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Progranulin (PGRN) is secreted by adipose tissue and has been linked to obesity, insulin resistance and type 2 diabetes mellitus.
|
30118483 |
2018 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This preliminary data is first suggesting that the antiplatelet and anticoagulant action of progranulin could have a physiological protective function against thrombotic disorders associated with obesity and atherosclerosis.
|
29863272 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently, progranulin was recognized as an adipokine involved in diet-induced obesity and insulin resistance revealing its metabolic function.
|
29226876 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
The adipokine progranulin has metabolic proprieties, playing a role in obesity and insulin resistance.
|
29499059 |
2018 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Serum progranulin levels are elevated in infertile women with obesity.
|
30229554 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Progranulin was first identified as a growth factor and, recently, it was characterised as an adipokine implicated in obesity, insulin resistance and rheumatic disease.
|
28651064 |
2017 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to compare nocturnal serum chemerin and progranulin levels between overweight/obese and normal-weight adolescents and to assess variations by sex, across different sleep stages and in relation to glucose metabolism.
|
27941174 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
More recently, progranulin was recognized as an adipokine involved in diet-induced obesity and insulin resistance, revealing its metabolic function.
|
24035620 |
2013 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Experimental study may clarify the PGRN role in obesity etiology through metabolism regulation.
|
22766892 |
2012 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using this ELISA, we assessed circulating progranulin in a cross-sectional study of 209 subjects with a wide range of obesity, body fat distribution, insulin sensitivity, and glucose tolerance and in 60 individuals with normal (NGT) or impaired (IGT) glucose tolerance or type 2 diabetes before and after a 4-week physical training program.
|
19056610 |
2009 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transcriptome analyses show that the progranulin gene is induced in numerous situations that vary from obesity to the transcriptional response of cells to antineoplastic drugs.
|
12973694 |
2003 |