GRN, granulin precursor, 2896

N. diseases: 412; N. variants: 66
Disease: Degenerative polyarthritis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.060 AlteredExpression disease BEFREE Median PGRN levels in HA patients was 349.1 ng/mL (232.8-415.6 ng/mL) and in OA patients 148.3 ng/mL (112.1-275.3 ng/mL) with statistically significant differences between both groups (P < 0.015). 30488982 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.060 Biomarker disease BEFREE We recently published a visualized protocol to demonstrate a surgically-induced mouse model for examining the protective role of PGRN in degenerative osteoarthritis (Zhao et al., J Vis Exp:e50924, 2014). 29956284 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.060 Biomarker disease BEFREE In addition, the protective role of PGRN has also been demonstrated in osteoarthritis, inflammatory bowel disease, and psoriasis. 27527809 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.060 Biomarker disease BEFREE Additionally, intra-articular delivery of PGRN protects against osteoarthritis (OA) progression. 29258611 2017
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.060 AlteredExpression disease BEFREE Both miR-29b-3p and PGRN were up-regulated in cartilage tissue from patients with OA. 28609022 2017
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.060 AlteredExpression disease BEFREE Moreover, PGRN mRNA and protein expression is increased in cartilage, synovial and infrapatellar fat pad tissue samples from OA patients. 26853108 2016