GRN, granulin precursor, 2896

N. diseases: 412; N. variants: 66
Disease: Tumor Progression ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.060 Biomarker phenotype BEFREE However, BALF progranulin associated with time to tumor progression (r = 0.61; p = 0.04). 30357709 2019
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.060 Biomarker phenotype BEFREE Subcutaneous injections of progranulin or its active domain (GRN A) induced lung metastases in breast cancer xenograft models, supporting a major role for progranulin in cancer progression. 30454027 2018
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.060 Biomarker phenotype BEFREE Accurate measurement of progranulin (PGRN) in the circulation and in the tumor microenvironment is essential for understanding its role in cancer progression and metastasis. 29956276 2018
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.060 Biomarker phenotype BEFREE Gα12 and Gα13, encoded by GNA12 and GNA13, respectively, are referred to as the GEP oncogene and are implicated in tumor progression. 26804165 2016
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.060 Biomarker phenotype BEFREE Granulin-epithelin precursor (GEP) is a pluripotent secretory growth factor which promotes cancer progression in a number of human cancers. 25115442 2014
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.060 Biomarker phenotype BEFREE Progranulin (pgrn; PC-cell-derived growth factor, epithelin precursor, or acrogranin) has been identified recently as an autocrine regulator of tumorigenesis in several cancer cells including SW-13 adrenal carcinomas and some breast cancers, but how pgrn promotes tumor progression is not well understood. 12359772 2002