|
Obesity
|
0.030 |
Biomarker
|
disease |
BEFREE |
Correlation of A2bAR and KLF4/KLF15 with Obesity-Dyslipidemia Induced Inflammation in Uygur Population.
|
27199507 |
2016 |
|
Obesity
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that adipose inflammation under conditions of obesity suppresses adipolin expression via JNK-dependent down-regulation of KLF15 in adipocytes.
|
24358263 |
2013 |
|
Coronary Arteriosclerosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we identify EZH2 as an epigenetic regulator of KLF15 along with DNA hypermethylation, and we propose a novel mechanism through which coronary heart disease reprograms the expression of both intermediate enzymes and upstream regulators of cardiac metabolism such as KLF15.
|
30089854 |
2019 |
|
Coronary Arteriosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Transcriptomic bioinformatics, phenotyping of Klf15 knockout mice, Wnt-signaling-modulated hearts, and pressure overload and myocardial ischemia models were applied.
|
31582141 |
2019 |
|
Diabetic Nephropathy
|
0.020 |
Biomarker
|
disease |
BEFREE |
In conclusion, Jun, Ptgs2, Fn1, Cdk2, Fos, Hspa5, Hsp90b1, Hyou1, RHOB, CFH and KLF15 may be potential therapeutic targets for mesangial cells associated with DN, which may provide insight into DN treatment strategies.
|
31105790 |
2019 |
|
Vascular inflammations
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Similarly, perivascularly overexpression of KLF15 but not KLF15-ΔTAD in carotid arteries also attenuated Ang II-induced vascular inflammation and fibrosis.
|
30776250 |
2019 |
|
Chronic Kidney Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
In this review, we discuss recent advances and update our overview of the functions of KLF15 in kidney biology, hoping to provide new perspectives on the progression and therapy of Chronic Kidney Disease (CKD).
|
31523196 |
2019 |
|
Diabetic Nephropathy
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Biopsied kidney tissue samples were obtained from patients with primary membranous nephropathy or diabetic nephropathy in order to analyze the relationship between glomerular KLF15 expression and subsequent outcomes.
|
29901095 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
KLF15 suppresses cell growth and predicts prognosis in lung adenocarcinoma.
|
29990857 |
2018 |
|
Chronic Kidney Diseases
|
0.020 |
AlteredExpression
|
group |
BEFREE |
It is unknown if KLF15 expression is changed in CKD induced LVH, or whether expression is modulated by blood pressure reduction using angiotensin converting enzyme (ACE) inhibition.
|
29970016 |
2018 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
KLF15 promotes the proliferation and metastasis of lung adenocarcinoma cells and has potential as a cancer prognostic marker.
|
29299121 |
2017 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
KLF15 promotes the proliferation and metastasis of lung adenocarcinoma cells and has potential as a cancer prognostic marker.
|
29299121 |
2017 |
|
Neoplasm Metastasis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
And KLF15 expression was negatively correlated with clinical stage, lymphatic metastasis, and distant metastasis.
|
28421457 |
2017 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
Collectively, our findings suggest that KLF15 may have a significant effect on LADC cell survival, and that it represents a potential therapeutic and preventive biomarker for LADC prognosis and treatment.
|
29299121 |
2017 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The effect of KLF15 on cell growth and migration were explored <i>in vitro</i> by Western Blotting, CCK8 and colony formation assays, flow cytometry analysis and transwell migration assays, and <i>in vivo</i> by analysis of tumorigenesis in 5-week old BALB/c nude mice.
|
29299121 |
2017 |
|
Primary Focal Segmental Glomerulosclerosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Finally, the level of KLF15 expression in the podocytes and glomeruli from human biopsy specimens correlated with glucocorticoid responsiveness in 35 patients with minimal change disease or primary FSGS.
|
27288011 |
2017 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
So far, a role for KLF15 in carcinogenesis has not been established, in contrast to other members of the Kruppel-like family of transcription factors, and no rearrangements involving this gene have been documented to our knowledge.
|
26523541 |
2016 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
In addition, KLF15 has recently been implicated in the development of several human malignancies, including breast cancer.
|
25869021 |
2015 |
|
Vascular inflammations
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Kruppel-like factor 15 is critical for vascular inflammation.
|
23999430 |
2013 |
|
Primary Focal Segmental Glomerulosclerosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Finally, KLF15 expression was reduced in glomeruli isolated from HIV transgenic mice as well as in kidney biopsies from patients with HIV-associated nephropathy and idiopathic focal segmental glomerulosclerosis.
|
22493483 |
2012 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
LncRNA TTN-AS1 sponges miR-376a-3p to promote colorectal cancer progression via upregulating KLF15.
|
31610194 |
2020 |
|
Acute Promyelocytic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression of four Krüppel-like transcription factors (KLF), KLF4, KLF6, PLZF (promyelocytic leukemia zinc finger), and KLF15, are induced in TG neurons early during dexamethasone-induced reactivation.
|
31776270 |
2020 |
|
hypertensive nephropathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
First, we found that KLF15 expression was decreased in patients with hypertensive nephropathy.
|
31697927 |
2020 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In conclusions, TTN-AS1 promoted CRC proliferation and invasion through miR-376a-3p/KLF15 axis.
|
31610194 |
2020 |
|
Promyelocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression of four Krüppel-like transcription factors (KLF), KLF4, KLF6, PLZF (promyelocytic leukemia zinc finger), and KLF15, are induced in TG neurons early during dexamethasone-induced reactivation.
|
31776270 |
2020 |