KLF15, Kruppel like factor 15, 28999

N. diseases: 80; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.300 Biomarker group CTD_human Identification of genes potentially involved in the acquisition of androgen-independent and metastatic tumor growth in an autochthonous genetically engineered mouse prostate cancer model. 17013881 2007
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.300 Biomarker disease CTD_human Identification of genes potentially involved in the acquisition of androgen-independent and metastatic tumor growth in an autochthonous genetically engineered mouse prostate cancer model. 17013881 2007
CUI: C0003486
Disease: Aortic Aneurysm
Aortic Aneurysm 		0.210 GeneticVariation disease BEFREE Mice deficient in Klf15 develop heart failure and aortic aneurysms in a p53-dependent and p300 acetyltransferase-dependent fashion. 20375365 2010
CUI: C0003486
Disease: Aortic Aneurysm
Aortic Aneurysm 		0.210 Biomarker disease MGD
CUI: C0265010
Disease: Ruptured thoracic aortic aneurysm
Ruptured thoracic aortic aneurysm 		0.200 Biomarker disease MGD
CUI: C0265012
Disease: Ruptured abdominal aortic aneurysm
Ruptured abdominal aortic aneurysm 		0.200 Biomarker disease MGD
CUI: C0741160
Disease: Aortic Aneurysm, Ruptured
Aortic Aneurysm, Ruptured 		0.200 Biomarker disease MGD
CUI: C1305122
Disease: Thoracoabdominal aortic aneurysm, ruptured
Thoracoabdominal aortic aneurysm, ruptured 		0.200 Biomarker disease MGD
CUI: C0002170
Disease: Alopecia
Alopecia 		0.100 GeneticVariation disease GWASCAT Genetic prediction of male pattern baldness. 28196072 2017
CUI: C0029489
Disease: Other alopecia
Other alopecia 		0.100 GeneticVariation phenotype GWASCAT GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk. 29146897 2017
CUI: C0162311
Disease: Androgenetic Alopecia
Androgenetic Alopecia 		0.100 GeneticVariation disease GWASCAT GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk. 29146897 2017
CUI: C2676272
Disease: Alopecia, Androgenetic, 3
Alopecia, Androgenetic, 3 		0.100 GeneticVariation disease GWASCAT GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk. 29146897 2017
CUI: C2678038
Disease: Alopecia, Androgenetic, 2
Alopecia, Androgenetic, 2 		0.100 GeneticVariation disease GWASCAT GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk. 29146897 2017
CUI: C4049090
Disease: Alopecia, Androgenetic, 1
Alopecia, Androgenetic, 1 		0.100 GeneticVariation disease GWASCAT GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk. 29146897 2017
CUI: C4083212
Disease: Alopecia, Male Pattern
Alopecia, Male Pattern 		0.100 GeneticVariation disease GWASCAT GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk. 29146897 2017
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.070 Biomarker disease BEFREE KLF15 may therefore be an effective therapeutic target for the treatment of heart failure and other cardiovascular diseases. 30831134 2019
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.070 GeneticVariation disease BEFREE It also discusses our recent paper that described the contribution of genetic variants in <i>KLF15</i> to the development of LVH and heart failure in high-risk patients. 29702551 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.070 AlteredExpression disease BEFREE Krüppel-like factor 15 (KLF15) has recently emerged as a critical transcriptional regulator of BCAA metabolism, and the absence of this transcription factor contributes to severe pathologies such as Duchenne muscular dystrophy and heart failure. 29288718 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.070 Biomarker disease BEFREE KLF15 may constitute an efficient candidate drug for the treatment of heart failure and other cardiovascular diseases. 28336438 2017
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.070 AlteredExpression disease BEFREE We show in human heart samples that KLF15 is induced after birth and reduced in heart failure, a myocardial expression pattern that parallels reliance on lipid oxidation. 24407292 2014
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.070 Biomarker disease BEFREE Mice deficient in Klf15 develop heart failure and aortic aneurysms in a p53-dependent and p300 acetyltransferase-dependent fashion. 20375365 2010
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.070 AlteredExpression disease BEFREE The expression levels of KLF15 and GLUT4 were decreased at the left ventricular hypertrophy and congestive heart failure stage in a rat model. 19720047 2009
CUI: C0018801
Disease: Heart failure
Heart failure 		0.060 Biomarker disease BEFREE KLF15 may therefore be an effective therapeutic target for the treatment of heart failure and other cardiovascular diseases. 30831134 2019
CUI: C0018801
Disease: Heart failure
Heart failure 		0.060 AlteredExpression disease BEFREE Krüppel-like factor 15 (KLF15) has recently emerged as a critical transcriptional regulator of BCAA metabolism, and the absence of this transcription factor contributes to severe pathologies such as Duchenne muscular dystrophy and heart failure. 29288718 2018
CUI: C0018801
Disease: Heart failure
Heart failure 		0.060 GeneticVariation disease BEFREE It also discusses our recent paper that described the contribution of genetic variants in <i>KLF15</i> to the development of LVH and heart failure in high-risk patients. 29702551 2018