ANPEP, alanyl aminopeptidase, membrane, 290

N. diseases: 280; N. variants: 4
Disease: Hypertensive disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.050 Biomarker group BEFREE Though, ACE inhibition is adequate to reduce SBP, targeting NEP and APN along with ACE is beneficial in tackling hypertension and associated fibrosis of heart. 31715212 2020
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.050 Biomarker group BEFREE Furthermore, APN, CTRP1, and IL-6 were three factors that influenced the STOD of EH patients, among which CTRP1 and IL6 were positively related with the complication of hypertension and STOD. 31772610 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.050 Biomarker group BEFREE Angiotensin II (Ang II)‑induced hypertension resulted in a significant decrease of APN and AdipoR1 and AdipoR2 in the perivascular adipocytes and vascular cells. 29115432 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.050 AlteredExpression group BEFREE However, the regulation of APN expression in hypertension remains to be explored. 27974594 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.050 Biomarker group LHGDN Dysregulation of central APN has been linked to the pathogenesis of hypertension in the spontaneously hypertensive rat. 18008160 2008