Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.310 Biomarker disease CTD_human Altered expression of genes involved in GABAergic transmission and neuromodulation of granule cell activity in the cerebellum of schizophrenia patients. 18923069 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.310 Biomarker disease BEFREE Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia. 16325263 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.300 Biomarker disease PSYGENET We identified strong associations to individual disorders, such as growth hormone releasing hormone (GHRH) with anxiety disorders, prolactin regulatory element (PREB) with eating disorders, ionotropic kainate glutamate receptor 5 (GRIK5) with bipolar disorder and several SNPs associated to several disorders, that may represent individual and related disease susceptibility factors. 19086053 2009
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.200 Biomarker disease RGD Functional cooperation between KA2 and GluR6 subunits is involved in the ischemic brain injury. 17639597 2007
CUI: C0270824
Disease: Visual seizure
Visual seizure 		0.200 Biomarker disease RGD Antagonists of GLU(K5)-containing kainate receptors prevent pilocarpine-induced limbic seizures. 12080343 2002
CUI: C0014556
Disease: Epilepsy, Temporal Lobe
Epilepsy, Temporal Lobe 		0.200 Biomarker disease RGD Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities. 11226670 2001
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.100 GeneticVariation disease GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
CUI: C0015397
Disease: Disorder of eye
Disorder of eye 		0.010 Biomarker group BEFREE Our findings also add dimension to the understanding of the biology driven by glutamate receptors such as GRIK5 (also referred to as GLUK5 in protein form) and to mechanisms contributing to human eye diseases. 30827500 2019
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		0.010 Biomarker disease BEFREE Gene ontology analysis shows that the glutamate receptor signaling pathway (P = 8.009E-07, with false discovery rate (FDR) < 5%), GRIK5 sub network (P = 2.887E-06, FDR < 5%), abnormal gait (P = 3.657E-06, FDR < 5%), REACTOME_SIGNALING_BY_ERBB2 (P = 5.161E-06, FDR < 5%), and abnormal nervous system physiology (P = 5.239E-06, FDR < 5%) were associated with ADHD. 30738099 2019
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.010 GeneticVariation disease BEFREE The most surprising negative result is for the GRIK2 (TAA)(n) polymorphism, which has previously shown association with age of onset in four independent populations with Huntington's disease. 17018562 2007