We investigated the possible association between two NMDA subunit gene polymorphisms (GRIN2B rs2284411 and GRIN2Ars2229193) and treatment response to methylphenidate (MPH) in attention-deficit/hyperactivity disorder (ADHD).
The purpose of this study was to investigate the association between the ionotropic and glutamate receptors, N-methyl D-asparate 2A (GRIN2A) and 2B (GRIN2B), and the metabotropic glutamate receptor mGluR7 (GRM7) gene polymorphisms and attention-deficit hyperactivity disorder (ADHD) in Korean population.
We tested for linkage between the alleles and haplotypes of four polymorphisms at the GRIN2A locus and ADHD in our sample of 183 nuclear families with 229 affected children.