Disease: Neuralgia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 AlteredExpression phenotype BEFREE This study aims to determine whether caveolin-1 (Cav-1) participates in the process of diabetic neuropathic pain by directly regulating the expression of toll-like receptor 4 (TLR4) and the subsequent phosphorylation of N-methyl-D-aspartate receptor 2B subunit (NR2B) in the spinal cord. 31318049 2020
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 PosttranslationalModification phenotype BEFREE ROR2 in the spinal cord regulates neuropathic pain via phosphorylation of GluN2B, suggesting a potential target for prevention and relief of neuropathic pain. 30916039 2019
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE Chemokine receptor CCR2 contributes to neuropathic pain and the associated depression via increasing NR2B-mediated currents in both D1 and D2 dopamine receptor-containing medium spiny neurons in the nucleus accumbens shell. 29993042 2018
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE Furthermore, application of T10 and/or MK-801 significantly inhibited the activation of microglia and astrocyte and phosphorylation of STAT<sub>3</sub> and NR2B in the spinal dorsal horn induced by chronic neuropathic pain. 29166839 2018
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 AlteredExpression phenotype BEFREE Excessive increase in NMDAr/GluN2B activity has been associated with various disorders such neuropathic pain and neuronal death following hypoxia. 28511693 2017
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 AlteredExpression phenotype BEFREE In addition, decreased GR nuclear translocation with normal mechanical nociception and hypoalgesia of thermal nociception were observed in OB-Sham rats.Intrathecal injection (i.t.) of GR agonist dexamethasone (Dex; 4 μg/rat/day for 1 week) eliminated the attenuating effect of depression on nociceptive hypersensitivity in OB-SNL rats and aggravated neuropathic pain in NOB-SNL rats, which was associated with the up-regulation of brain-derived neurotrophic factor (BDNF), TrkB and NR2B expression in the spinal dorsal horn. 28579944 2017
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 AlteredExpression phenotype BEFREE Collectively, our findings suggest that CFSS potentiates synaptic efficiency of the BLA-CeA pathway, leading to the activation of GluN2B-NMDA receptors and sensitization of CeA neurons, which subsequently facilitate pain-related synaptic plasticity of the PB-CeA pathway, thereby exacerbating SNI-induced neuropathic pain. 28225710 2017
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 AlteredExpression phenotype BEFREE MiRNA mimics were then used to examine the role of miR-539 in the ACC in modulation of NR2B subunit expression and neuropathic pain in rats. 28379535 2017
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE Loss of Arrb2 also results in prolongation of inflammatory pain and neuropathic pain and enhancement of GluN2B-mediated NMDA currents in spinal lamina IIo not lamina I neurons. 27538456 2016
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE GRs activated spinal Akt-nNOS/NR2B pathway play important roles in the development of neuropathic pain in a time-dependent manner. 24562683 2014
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE In particular, agents that are selective for receptors that include the NR2B subunit preclinically have a substantially better profile for treating neuropathic pain than do current NMDA antagonists; some emerging clinical evidence supports this view. 16178757 2005