|
Depressive disorder
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
In this first study in humans to examine the joint effects of prenatal and postnatal environmental exposures, we report that GR gene (NR3C1) 1-F promoter methylation in infants is elevated in the presence of increased maternal postnatal depression following low prenatal depression, and that this effect is reversed by self-reported stroking of the infants by their mothers over the first weeks of life.
|
25942041 |
2015 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Differential effects of DRN GR deletion in female mice may provide insight into the greater incidence of depression and specific depression symptoms in women.
|
31846734 |
2020 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Effects of cytokines on glucocorticoid receptor expression and function. Glucocorticoid resistance and relevance to depression.
|
10442170 |
1999 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In addition, six glucocorticoid receptor pathway genes (Slc22a5, Aqp1, Stat5a, Ampd3, Plekhf1, and Cyb561) were upregulated in GF mice, and of these only two (Stat5a and Ampd3) were upregulated in LPS-treated mice, whereas the shared gene, Stat5a, was downregulated in "depression microbiota" recipient mice.
|
30194287 |
2018 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In the context of environmental stress, a functional variant in the glucocorticoid receptor co-chaperone FKBP5 gene has been repeatedly shown to increase risk for psychiatric illness, including depression.
|
27485401 |
2017 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Haplotypic variation in the regulatory region of the NR3C1 may increase vulnerability to depressive disorders requiring hospital admission, but is not associated with self-reported symptoms.
|
21477816 |
2011 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Mothers with depression also had lower NR3C1 than other mothers (p < 0.003) but did not differ in OXTR.
|
29580902 |
2019 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
APPL2 Tg mice displayed higher GR activity and less capacity of neurogenesis at olfactory system with less olfactory sensitivity than WT mice, indicating that APPL2 could be a potential therapeutic target for depression and olfactory deficits.
|
29675572 |
2018 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, we tested the leukocyte mRNA expression levels of genes belonging to glucocorticoid receptor (GR) function (FKBP-4, FKBP-5, and GR), inflammation (interleukin (IL)-1α, IL-1β, IL-4, IL-6, IL-7, IL-8, IL-10, macrophage inhibiting factor (MIF), and tumor necrosis factor (TNF)-α), and neuroplasticity (brain-derived neurotrophic factor (BDNF), p11 and VGF), in healthy controls (n=34) and depressed patients (n=74), before and after 8 weeks of treatment with escitalopram or nortriptyline, as part of the Genome-based Therapeutic Drugs for Depression study.
|
22990943 |
2013 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Glucocorticoid receptor dysfunction orchestrates inflammasome effects on chronic obstructive pulmonary disease-induced depression: A potential mechanism underlying the cross talk between lung and brain.
|
30738183 |
2019 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In this review we summarize different approaches used to alter or eliminate glucocorticoid receptor expression and function, and discuss their relevance as models for depression.
|
17524489 |
2008 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In a cross-sectional genetic association study of 526 white outpatients with chronic coronary heart disease, we examined whether haplotypes of the glucocorticoid receptor gene (NR3C1) are associated with depression.
|
19783104 |
2009 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Recently, modulation of glucocorticoid receptor (GR) and serotonin receptor 1A (5-HTR1A) were implicated in mechanism(s) leading to depression.
|
15885359 |
2005 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Glucocorticoid receptor gene modulates severity of depression in women with crack cocaine addiction.
|
27397864 |
2016 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that hypermethylation at the NR3C1 exon 1F may occur in depression.
|
29793048 |
2018 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this review, we will focus on the GR as a key player in the precipitation, development and resolution of depression.
|
20399565 |
2011 |
|
Depressive disorder
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
The glucocorticoid receptor gene (NR3C1) displayed different methylation patterns in chronic stress and depression.
|
27998510 |
2017 |
|
Depressive disorder
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Conclusively: (1) depression in females may result from a gene × childhood-adversity interaction and/or a dysregulated epigenetic programming of MAOA; (2) childhood-adversity subtypes may differentially impact DNA methylation at NR3C1; (3) baseline MAOA-genotypic variations may affect the extent of NR3C1 methylation.
|
23449091 |
2013 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The study showed that altered phosphorylation of GR could contribute to impaired GR function related to the pathophysiology of depression.
|
23123359 |
2013 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Epigenetics and the glucocorticoid receptor: A review of the implications in depression.
|
27344028 |
2016 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
ACS patients with higher NR3C1 1 F exon methylation levels were at higher risk of developing depressive disorder within 2 weeks of ACS.
|
30408722 |
2019 |
|
Depressive disorder
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Most studies showed BDNF and NR3C1 gene methylation levels were correlated with depression while the connection of SLC6A4 and depression was conflicting.
|
28645747 |
2017 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In addition, GR and corticotropin-releasing hormone receptor 1 (CRHR1) genotypes contributed significantly to psychosis measures and CRHR1 contributed significantly to depression severity rating.
|
24166410 |
2014 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Pain and depressive-like behavior were measured over 14 days and brain-derived neurotrophic factor (BDNF; a factor involved in nociception and depression) and glucocorticoid receptor (GR; a stress-related receptor) expression were measured on day 14.
|
31815911 |
2019 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Using high throughput technologies for the identification of genes regulated by glucocorticoid receptor (GR) and MR in brain areas responsible for specific symptoms of stress-related disorders will yield potential new drug targets for the treatment of depression and anxiety.
|
11566214 |
2001 |