|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Depression has been linked to dysfunction of the intracellular response system to corticosteroids at the level of the hippocampus (HC) and prefrontal cortex (PFC) with a notable role of the glucocorticoid receptor (GR) and its co-chaperones (FKBP5 and FKBP4).
|
25666308 |
2015 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Glucocorticoid receptor polymorphism is associated with major depression and predominance of depression in the course of bipolar disorder.
|
21764460 |
2011 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Glucocorticoid receptor gene modulates severity of depression in women with crack cocaine addiction.
|
27397864 |
2016 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Glucocorticoid receptor dysfunction orchestrates inflammasome effects on chronic obstructive pulmonary disease-induced depression: A potential mechanism underlying the cross talk between lung and brain.
|
30738183 |
2019 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
ACS patients with higher NR3C1 1 F exon methylation levels were at higher risk of developing depressive disorder within 2 weeks of ACS.
|
30408722 |
2019 |
|
Depressive disorder
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Additionally, a higher NR3C1 methylation level at CpG 2 was associated with depression incidence 2 years later in this population.
|
29432878 |
2018 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Allelic variants of the glucocorticoid receptor (GR) gene contribute significantly to both cortisol levels and to measures of psychosis; corticotropin-releasing hormone receptor 1 variants contribute to measures of depression and psychosis.
|
24933348 |
2015 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Altered DNA methylation (DNAm) levels of hypothalamic-pituitary-adrenal (HPA) axis genes has been associated with exposure to childhood maltreatment (CM) and depression; however, it is unknown whether CM and depression have joint and potentially interacting effects on the glucocorticoid receptor (NR3C1) DNAm.
|
27475889 |
2016 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
APPL2 Tg mice displayed higher GR activity and less capacity of neurogenesis at olfactory system with less olfactory sensitivity than WT mice, indicating that APPL2 could be a potential therapeutic target for depression and olfactory deficits.
|
29675572 |
2018 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Bcl1 polymorphism of the glucocorticoid receptor gene and treatment response to milnacipran and fluvoxamine in Japanese patients with depression.
|
25358426 |
2014 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Bcl1 polymorphism of the glucocorticoid receptor gene and treatment response to milnacipran and fluvoxamine in Japanese patients with depression.
|
25358426 |
2014 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Both GR gene polymorphisms and childhood adversity are known to be associated with increased risk for depression.
|
19051288 |
2009 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Combining both models resulted in 22 new and confirmed HSP90-independent NR3C1 inhibitors, providing two scaffolds (i.e., pyrimidine and pyrazolo-pyrimidine), which could potentially be of interest in the treatment of depression (i.e., inhibiting the glucocorticoid receptor (i.e., NR3C1), while leaving its chaperone, HSP90, unaffected).
|
29658791 |
2018 |
|
Depressive disorder
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Conclusively: (1) depression in females may result from a gene × childhood-adversity interaction and/or a dysregulated epigenetic programming of MAOA; (2) childhood-adversity subtypes may differentially impact DNA methylation at NR3C1; (3) baseline MAOA-genotypic variations may affect the extent of NR3C1 methylation.
|
23449091 |
2013 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Considering possible confounding effects of alcohol and/or depression, we conclude that chronic cocaine use is associated with lower NR3C1 gene expression suggesting possible direct effects of the drug on the biological adaptation of stress-related genes.
|
29761890 |
2019 |
|
Depressive disorder
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Controlling for relevant covariates, infants whose mothers reported depression during pregnancy and showed greater methylation of placental NR3C1 CpG2 had poorer self-regulation, more hypotonia, and more lethargy than infants whose mothers did not report depression.
|
24135662 |
2013 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Differential effects of DRN GR deletion in female mice may provide insight into the greater incidence of depression and specific depression symptoms in women.
|
31846734 |
2020 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Effects of cytokines on glucocorticoid receptor expression and function. Glucocorticoid resistance and relevance to depression.
|
10442170 |
1999 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Epigenetics and the glucocorticoid receptor: A review of the implications in depression.
|
27344028 |
2016 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
FKBP5 and specific microRNAs via glucocorticoid receptor in the basolateral amygdala involved in the susceptibility to depressive disorder in early adolescent stressed rats.
|
28826069 |
2017 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
FKBP5 is a glucocorticoid receptor-regulating co-chaperone of hsp-90 and, therefore, is suggested to play a role in the regulation of the hypothalamic-pituitary-adrenocortical system and the pathophysiology of depression.
|
20047716 |
2010 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Given the role of GR-mediated negative feedback in mediating response to stress, and the clear link between stress and depression, it is plausible that polymorphisms in the GR gene (NR3C1) act to increase susceptibility.
|
19089807 |
2009 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Haplotypic variation in the regulatory region of the NR3C1 may increase vulnerability to depressive disorders requiring hospital admission, but is not associated with self-reported symptoms.
|
21477816 |
2011 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In a cross-sectional genetic association study of 526 white outpatients with chronic coronary heart disease, we examined whether haplotypes of the glucocorticoid receptor gene (NR3C1) are associated with depression.
|
19783104 |
2009 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In addition, GR and corticotropin-releasing hormone receptor 1 (CRHR1) genotypes contributed significantly to psychosis measures and CRHR1 contributed significantly to depression severity rating.
|
24166410 |
2014 |