|
Rheumatoid Arthritis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Cannabinoid Receptor 2 Agonist JWH-015 Inhibits Interleukin-1β-Induced Inflammation in Rheumatoid Arthritis Synovial Fibroblasts and in Adjuvant Induced Arthritis Rat via Glucocorticoid Receptor.
|
31139184 |
2019 |
|
Rheumatoid Arthritis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We aimed to test whether the functional polymorphisms of the GR encoding gene (NR3C1) are associated with susceptibility to RA and with various clinical signs and symptoms.
|
31820730 |
2019 |
|
Rheumatoid Arthritis
|
0.300 |
Biomarker
|
disease |
BEFREE |
The dissociated agonists of the glucocorticoid receptor are a novel class of agents in clinical development for rheumatoid arthritis.
|
29112329 |
2018 |
|
Rheumatoid Arthritis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Improved disease activity with fosdagrocorat (PF-04171327), a partial agonist of the glucocorticoid receptor, in patients with rheumatoid arthritis: a Phase 2 randomized study.
|
28328159 |
2017 |
|
Rheumatoid Arthritis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
GLCCI1 genotype, but not GR genotypes, was associated with improvement in DAS in male patients with RA.
|
25724472 |
2015 |
|
Rheumatoid Arthritis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We examined the relation between the presence of these GR polymorphisms and level of disease activity and disease course of RA during pregnancy and postpartum.
|
22889053 |
2012 |
|
Rheumatoid Arthritis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Here we show that the GR-modulating substance compound A (CpdA), which does not induce GR dimerization, still suppresses proinflammatory cytokines in fibroblast-like synovial cells from patients with RA and in osteoblasts.
|
21233489 |
2011 |
|
Rheumatoid Arthritis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The presence of GR polymorphisms was assessed in healthy controls (n = 5033), and in RA patients (n = 368).
|
20727199 |
2010 |
|
Rheumatoid Arthritis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Quantitation of glucocorticoid receptor alpha and NF-κB pathway mRNA and its correlation with disease activity in rheumatoid arthritis patients.
|
21128210 |
2010 |
|
Rheumatoid Arthritis
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
Glucocorticoid receptor variants may predispose to rheumatoid arthritis susceptibility.
|
18830906 |
2009 |
|
Rheumatoid Arthritis
|
0.300 |
Biomarker
|
disease |
BEFREE |
To analyze glucocorticoid (GC) sensitivity using intravenous very low dose dexamethasone suppression test (IV-VLD-DST) in patients with rheumatoid arthritis (RA) and its correlation with glucocorticoid receptor alpha-isoform (GRalpha) gene expression.
|
19347182 |
2009 |
|
Rheumatoid Arthritis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Glucocorticoid receptor variants may predispose to rheumatoid arthritis susceptibility.
|
18830906 |
2009 |
|
Rheumatoid Arthritis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Quantitative polymerase chain reaction was performed to detect the tumor necrosis factor alpha (TNFalpha)-induced cytokine gene expression of interleukin-1beta (IL-1beta) and to investigate the effects of DEX and CpdA in RA fibroblast-like synoviocytes (FLS) transfected with small interfering RNA (siRNA) against GR (siGR) compared with nontransfected cells.
|
19877072 |
2009 |
|
Rheumatoid Arthritis
|
0.300 |
Biomarker
|
disease |
RGD |
Modeling corticosteroid effects in a rat model of rheumatoid arthritis I: mechanistic disease progression model for the time course of collagen-induced arthritis in Lewis rats.
|
18448865 |
2008 |
|
Rheumatoid Arthritis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In this study of the most comprehensive coverage of GR polymorphisms with RA, no significant contributing role for GR polymorphisms with RA was found.
|
17532759 |
2007 |
|
Rheumatoid Arthritis
|
0.300 |
Biomarker
|
disease |
LHGDN |
Glucocorticoid receptor beta in acute and chronic inflammatory conditions: clinical implications.
|
16446173 |
2006 |
|
Rheumatoid Arthritis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The level of GR beta mRNA expression was not related to the inflammatory markers or the disease activity score 28 for the RA patients, and it was not related to the Bath ankylosing spondylitis disease activity index for the AS patients.
|
16134770 |
2005 |
|
Rheumatoid Arthritis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In early RA a significantly lower GR expression was found compared to controls.
|
12114259 |
2002 |
|
Rheumatoid Arthritis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Our findings show an association between RA and a previously unreported polymorphism in the hGR gene.
|
11708406 |
2001 |
|
Rheumatoid Arthritis
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
A human glucocorticoid receptor gene variant that increases the stability of the glucocorticoid receptor beta-isoform mRNA is associated with rheumatoid arthritis.
|
11708406 |
2001 |