Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Recent evidence has suggested that impaired glucocorticoid receptor (GR), the signaling of key molecules of the HPA axis, plays a key role in the behavioral and neuroendorcrine alterations of major depression.
|
31837802 |
2020 |
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Glucocorticoid Receptor Genetic Variants and Response to Fluoxetine in Major Depressive Disorder.
|
28641498 |
2018 |
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
After conservative correction of Type-I-error to obtain reliable p values, one SNP in the NR3C1 gene, namely rs6195, showed a significant association with the presence of a major depression (p = 0.048) in females.
|
27549215 |
2017 |
Unipolar Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Aim Based on the AGENDA trial dataset, we analysed whether an intervention with SSRI versus placebo decreases the GRα mRNA expression in peripheral blood cells in healthy first-degree relatives of patients with major depression.
|
26752119 |
2016 |
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Fifty-nine depressed individuals with major depressive disorder (n=33) or bipolar disorder (n=26), and 32 healthy individuals were genotyped for the glucocorticoid receptor BclI G/C polymorphism, and underwent functional magnetic resonance imaging during a monetary reward task.
|
26349556 |
2016 |
Unipolar Depression
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Glucocorticoid receptor DNA methylation, childhood maltreatment and major depression.
|
27475889 |
2016 |
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
GLUCOCORTICOID RECEPTOR-RELATED GENES: GENOTYPE AND BRAIN GENE EXPRESSION RELATIONSHIPS TO SUICIDE AND MAJOR DEPRESSIVE DISORDER.
|
27030168 |
2016 |
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Accumulation of cytoplasmic glucocorticoid receptor is related to elevation of FKBP5 in lymphocytes of depressed patients.
|
25355489 |
2015 |
Unipolar Depression
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Taken together, these results indicate that CDK5 is an integral component of stress response and major depression with regulatory means specific to different stressors, brain areas and diseases in part through changing phosphorylation of GR.
|
26057048 |
2015 |
Unipolar Depression
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Glucocorticoid receptor gene (NR3C1) promoter is hypermethylated in Thai females with major depressive disorder.
|
26782558 |
2015 |
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Clinical characteristics of inflammation-associated depression: Monocyte gene expression is age-related in major depressive disorder.
|
25150007 |
2015 |
Unipolar Depression
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Association between glucocorticoid receptor methylation and hippocampal subfields in major depressive disorder.
|
24465557 |
2014 |
Unipolar Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Inflammatory activation is associated with a reduced glucocorticoid receptor alpha/beta expression ratio in monocytes of inpatients with melancholic major depressive disorder.
|
24424390 |
2014 |
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Inflammatory activation is associated with a reduced glucocorticoid receptor alpha/beta expression ratio in monocytes of inpatients with melancholic major depressive disorder.
|
24424390 |
2014 |
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Association between glucocorticoid receptor methylation and hippocampal subfields in major depressive disorder.
|
24465557 |
2014 |
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
FKBP5 genotype-dependent DNA methylation and mRNA regulation after psychosocial stress in remitted depression and healthy controls.
|
25522420 |
2014 |
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Phosphorylation of leukocyte glucocorticoid receptor in patients with current episode of major depressive disorder.
|
23123359 |
2013 |
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Several genes, including FKBP5 and DUSP1, previously associated with the pathophysiology of major depression, were found to be reliable markers of GR-activation.
|
22237309 |
2012 |
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we investigated if polymorphism of the glucocorticoid receptor gene (NR3C1), involved in the regulation of HPA axis, may alter susceptibility as well as the course of major depressive disorder and bipolar disorder.
|
21764460 |
2011 |
Unipolar Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Differential expression of glucocorticoid receptor transcripts in major depressive disorder is not epigenetically programmed.
|
19782477 |
2010 |
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this overview, currently known clinically relevant GR and MR polymorphisms are discussed in relation to mood disorders (both unipolar depression and bipolar disorder) and cognitive function.
|
19906241 |
2009 |
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Modulation of glucocorticoid receptor nuclear translocation in neurons by immunophilins FKBP51 and FKBP52: implications for major depressive disorder.
|
19545546 |
2009 |
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Glucocorticoid receptor polymorphisms in major depression.
|
19906242 |
2009 |
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Unipolar depression is associated with DNA variants of the NR3C1 gene in our population.
|
18286599 |
2008 |
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Perturbations in HPA axis sensitivity to glucocorticoids implicated in the pathogenesis of major depression may result from functional alterations in the glucocorticoid receptor gene.
|
18246526 |
2008 |