|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Time-group interaction effects were found for several impulsivity scores, SCL-90R Global Severity Index, Paranoid Thoughts, and Depression subscales as well as for NR3C1 expression.
|
31812111 |
2020 |
|
Depressed mood
|
0.100 |
PosttranslationalModification
|
phenotype |
BEFREE |
Poisson regression with robust variance adjusted by gender, tobacco use, self-perceived stress, leisure activity, suicidal ideation, low cortisol levels and NR3C1 DNA methylation was performed and predicted risk factors for depression.
|
31731185 |
2020 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Differential effects of DRN GR deletion in female mice may provide insight into the greater incidence of depression and specific depression symptoms in women.
|
31846734 |
2020 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Pain and depressive-like behavior were measured over 14 days and brain-derived neurotrophic factor (BDNF; a factor involved in nociception and depression) and glucocorticoid receptor (GR; a stress-related receptor) expression were measured on day 14.
|
31815911 |
2019 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Considering possible confounding effects of alcohol and/or depression, we conclude that chronic cocaine use is associated with lower NR3C1 gene expression suggesting possible direct effects of the drug on the biological adaptation of stress-related genes.
|
29761890 |
2019 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Mothers with depression also had lower NR3C1 than other mothers (p < 0.003) but did not differ in OXTR.
|
29580902 |
2019 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Methylation of the glucocorticoid receptor gene associated with depression in patients with acute coronary syndrome.
|
30408722 |
2019 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Glucocorticoid receptor dysfunction orchestrates inflammasome effects on chronic obstructive pulmonary disease-induced depression: A potential mechanism underlying the cross talk between lung and brain.
|
30738183 |
2019 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Studies investigating Glucocorticoid Receptor (GR/NR3C1) in the brain have primarily focused on the forebrain, however in recent years, the hindbrain has become a region of interest for research into the development of anxiety and depression, though the role of GR signalling in the hindbrain remains poorly characterised.
|
30824750 |
2019 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The mineralocorticoid receptor (MR)/glucocorticoid receptor balance plays an important role in the pathophysiology of anxiety and depression.
|
30852427 |
2019 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In addition, six glucocorticoid receptor pathway genes (Slc22a5, Aqp1, Stat5a, Ampd3, Plekhf1, and Cyb561) were upregulated in GF mice, and of these only two (Stat5a and Ampd3) were upregulated in LPS-treated mice, whereas the shared gene, Stat5a, was downregulated in "depression microbiota" recipient mice.
|
30194287 |
2018 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
APPL2 Tg mice displayed higher GR activity and less capacity of neurogenesis at olfactory system with less olfactory sensitivity than WT mice, indicating that APPL2 could be a potential therapeutic target for depression and olfactory deficits.
|
29675572 |
2018 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The glucocorticoid receptor is dysfunctional in depression, and it is a direct target of miR-124.
|
29484897 |
2018 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Regulators of glucocorticoid receptor function in an animal model of depression and obesity.
|
29524264 |
2018 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Combining both models resulted in 22 new and confirmed HSP90-independent NR3C1 inhibitors, providing two scaffolds (i.e., pyrimidine and pyrazolo-pyrimidine), which could potentially be of interest in the treatment of depression (i.e., inhibiting the glucocorticoid receptor (i.e., NR3C1), while leaving its chaperone, HSP90, unaffected).
|
29658791 |
2018 |
|
Depressed mood
|
0.100 |
PosttranslationalModification
|
phenotype |
BEFREE |
Additionally, a higher NR3C1 methylation level at CpG 2 was associated with depression incidence 2 years later in this population.
|
29432878 |
2018 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We argue that better understanding the long-term effects of developmental stressors on PFC trkB, GR, and related factors may yield insights into risk for chronic, remitting depression and related neuropsychiatric illnesses.
|
30477984 |
2018 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The noradrenergic system and GR pathway in the locus coeruleus may be involved in the formation of depression concomitant with sleep disturbances.
|
29894769 |
2018 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
This meta-analysis demonstrates that the NR3C1 rs41423247 homozygous mutation may be a risk factor for depression.
|
30278546 |
2018 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The results do not support the hypothesis that GR dysregulation is aetiopathogenic in CFS and suggest that current and future endocrine cross-sectional studies in CFS may be vulnerable to the confounding influence of childhood trauma which is likely increased by comorbid depression.
|
29983634 |
2018 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Our findings suggest that hypermethylation at the NR3C1 exon 1F may occur in depression.
|
29793048 |
2018 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The present study shows that depression attenuates the mechanical allodynia and thermal hyperalgesia of neuropathic pain and suggests that altered spinal GR-BDNF-TrkB signaling may be one of the reasons for depression-induced hypoalgesia.
|
28579944 |
2017 |
|
Depressed mood
|
0.100 |
PosttranslationalModification
|
phenotype |
BEFREE |
Most studies showed BDNF and NR3C1 gene methylation levels were correlated with depression while the connection of SLC6A4 and depression was conflicting.
|
28645747 |
2017 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The hypo‑level of adrenocorticotropic hormone, noradrenaline and glucocorticoid receptor in serum and hypothalamus of depression‑like rats was enhanced by PHC.
|
28849191 |
2017 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Recent human studies show that DNA methylation changes of hypothesis-driven candidate gene regions, such as the promoter of the glucocorticoid receptor and the serotonin transporter, were associated with maternal depression in peripheral tissue samples of newborns' cord blood, infants' saliva, or adults' peripheral blood.
|
28714605 |
2017 |