Brugada Syndrome (disorder)
|
0.550 |
Biomarker
|
disease |
BEFREE |
We here screened the coding sequence, the flanking intronic regions as well as the 5' and 3'UTR regions of SCN5A gene and further five candidate genes (GPD1L, SCN1B, KCNE3, SCN4B, and MOG1) in a Tunisian family diagnosed with BrS.
|
31627867 |
2019 |
Brugada Syndrome (disorder)
|
0.550 |
GeneticVariation
|
disease |
BEFREE |
However, the molecular basis for the MOG1/Nav1.5 interaction and how the E83D substitution causes BrS remains unknown.
|
30282806 |
2018 |
Brugada Syndrome (disorder)
|
0.550 |
Biomarker
|
disease |
CLINGEN |
Compared with wild type MOG1 or control EGFP, mutant MOG1 with mutation E83D associated with Brugada syndrome significantly decreases the HR.
|
26903377 |
2016 |
Brugada Syndrome (disorder)
|
0.550 |
GeneticVariation
|
disease |
BEFREE |
The nonsense p.E61X genetic variation in the RANGRF gene has been postulated as responsible for Brugada syndrome although no clear association has been established.
|
24142675 |
2014 |
Brugada Syndrome (disorder)
|
0.550 |
GeneticVariation
|
disease |
ORPHANET |
The nonsense p.E61X genetic variation in the RANGRF gene has been postulated as responsible for Brugada syndrome although no clear association has been established.
|
24142675 |
2014 |
Brugada Syndrome (disorder)
|
0.550 |
Biomarker
|
disease |
CLINGEN |
The nonsense p.E61X genetic variation in the RANGRF gene has been postulated as responsible for Brugada syndrome although no clear association has been established.
|
24142675 |
2014 |
Brugada Syndrome (disorder)
|
0.550 |
Biomarker
|
disease |
CLINGEN |
Use of MOG1 to enhance Na(v)1.5 trafficking to PM may be a potential personalized therapeutic approach for some patients with Brugada syndrome, dilated cardiomyopathy, and sick sinus syndrome in the future.
|
23420830 |
2013 |
Brugada Syndrome (disorder)
|
0.550 |
Biomarker
|
disease |
BEFREE |
Previously, the genes SCN1B, SCN3B, MOG1, and KCND3 have been associated with BrS.
|
22284586 |
2012 |
Brugada Syndrome (disorder)
|
0.550 |
Biomarker
|
disease |
CLINGEN |
MOG1 was screened by direct sequencing in patients with BrS and idiopathic ventricular fibrillation.
|
21447824 |
2011 |
Brugada Syndrome (disorder)
|
0.550 |
Biomarker
|
disease |
CLINGEN |
A novel nonsense variant in Nav1.5 cofactor MOG1 eliminates its sodium current increasing effect and may increase the risk of arrhythmias.
|
21621375 |
2011 |
Brugada Syndrome (disorder)
|
0.550 |
Biomarker
|
disease |
BEFREE |
MOG1 was screened by direct sequencing in patients with BrS and idiopathic ventricular fibrillation.
|
21447824 |
2011 |
Brugada Syndrome (disorder)
|
0.550 |
Biomarker
|
disease |
CLINGEN |
Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav 1.5.
|
18184654 |
2008 |
Adenocarcinoma of lung (disorder)
|
0.300 |
Biomarker
|
disease |
CTD_human |
c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma.
|
27602772 |
2016 |
Experimental Autoimmune Encephalomyelitis
|
0.200 |
Biomarker
|
disease |
RGD |
The N-terminal domain of the myelin oligodendrocyte glycoprotein (MOG) induces acute demyelinating experimental autoimmune encephalomyelitis in the Lewis rat.
|
8557821 |
1995 |
Cardiac Arrest
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Paroxysmal ventricular tachycardia
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Sick Sinus Syndrome
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Syncope
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Supraventricular tachycardia
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Ventricular Fibrillation
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
First degree atrioventricular block
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Right bundle branch block
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Trifascicular block
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
ST segment elevation (finding)
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
AV Block First Degree by ECG Finding
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|