Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The timing of this Consensus Conference resulted from the convergence of many different factors, including new cytologic terminology developed at the Bethesda 2001 workshop and publication of the enrollment data from the National Cancer Institute's Atypical Squamous Cells of Undetermined Significance (ASC-US)/Low-Grade Squamous Intraepithelial Lesions (LSIL) Triage Study, otherwise known as ALTS.
|
12952506 |
2003 |
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
ISH HPV and HC HPV differed significantly in accurately predicting biopsy findings from ASC-US and LSIL cases.
|
12951683 |
2003 |
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
One hundred seven cases, including 23 negative cases, 34 with low-grade squamous intraepithelial lesion (LSIL), 16 with high-grade squamous intraepithelial lesion (HSIL), 29 with atypical squamous cells of uncertain significance (ASC-US), and 5 cases with ASC suspicious for HSIL (ASC-H), were evaluated for both p16 expression and HPV DNA.
|
15584047 |
2005 |
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
HPV-positive rates were determined in cases of low-grade squamous intraepithelial lesion (LSIL) and high-grade squamous intraepithelial lesion (HSIL), and follow-up rates of cervical intraepithelial neoplasia (CIN) were determined in HPV-positive and -negative cases of atypical squamous cells of unknown significance (ASC-US).
|
17091508 |
2006 |
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Primary screening with Hybrid Capture((R)) 2 (HC2) generally detects more than 90% of all CIN2, CIN3 or cancer cases, and is 25% (95% CI): 15-36%) relatively more sensitive than cytology at a cut-off of abnormal squamous cells of undetermined significance (ASC-US) (or low-grade squamous intraepithelial lesions (LSIL) if ASC-US unavailable), but is 6% (95% CI: 4-7%) relatively less specific.
|
18847555 |
2008 |
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Study subjects were 303 women who were HPV18 positive at enrollment into the Atypical Squamous Cells of Undetermined Significance (ASC-US) and Low-Grade Squamous Intraepithelial Lesion (LSIL) Triage Study.
|
19176451 |
2009 |
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Liquid-based cytology cases interpreted as high-grade squamous intraepithelial lesion (HSIL); low-grade squamous intraepithelial lesion (LSIL); atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H); and atypical squamous cells of undetermined significance (ASC-US) at Magee-Womens Hospital (Pittsburgh, Pennsylvania) were retrospectively identified for a 36-month period between July 1, 2005, and June 30, 2008, from women 50 years and older who also had hrHPV DNA test results.
|
20670132 |
2010 |
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The increased rates of HPV test performance and lower rates of HPV positivity in vaginal ASC-US and LSIL TPPTs compared with similarly abnormal cervical TPPTs were statistically significant (p <.05) by χ analysis.
|
20885164 |
2010 |
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In women with high-risk (HR)-HPV-positive atypical squamous cells of undetermined significance (ASC-US) and LSIL, sensitivity and specificity for detection of CIN3 were 90.6% and 48.6%, respectively.
|
22675168 |
2012 |
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thirty six of them (37.9%) showed abnormal anal cytology as follows: atypical squamous cells of undetermined significance (ASC-US) in 19 (20.0%), atypical squamous cells but cannot exclude HSIL (ASC-H) in 1 (1.1%), low-grade squamous intraepithelial lesion (LSIL) in 15 (15.8%), and high-grade squamous intraepithelial lesion (HSIL) in 1 (1.1%).
|
22558293 |
2012 |
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Literature search-targeted studies where the accuracy of APTIMA HPV and HC2 for detection of underlying CIN2/3+ was assessed concomitantly including verification of all cases of ASC-US and LSIL.
|
22610699 |
2013 |
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Considering CIN2+ in women with ASC-US and LSIL, mRNA testing was substantially more specific than the HC2 assay (ratio: 1.98 and 3.36, respectively; P < .001) but was less sensitive (ratio: 0.80 and 0.74, respectively; P < .001).
|
23881840 |
2013 |
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
All women with ASC-US/LSIL cytology who were referred to our colposcopy clinic from October 2010 to February 2014 were included.
|
25605209 |
2014 |
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Through the use of an immediate colposcopy threshold of ASC-US or worse for HR-HPV positive women and the use of a raised threshold of low-grade squamous intraepithelial lesion (LSIL) or worse for HR-HPV negative women, LBC and HR-HPV cotesting could provide the same effectiveness as LBC testing with HR-HPV triage for ASC-US at baseline tests.
|
24631450 |
2014 |
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two samples (1 ASC-US/1 LSIL) were excluded from the analysis due to inconclusive results of the histologic examination.
|
26230097 |
2015 |
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two hundred women (150 pre-menopausal and 50 post-menopausal) with ASC- US and LSIL cytology who attended the colposcopy clinic, Thammasat University Hospital, between March 2013 and August 2014 were included.
|
25824759 |
2015 |
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
HPV infection and p16 promoter methylation as predictors of ASC-US/LSIL progression.
|
26335500 |
2016 |
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate human papillomavirus (HPV) DNA testing and p16/Ki-67 staining for detecting cervical intraepithelial grade 2 or worse (CIN2+) and CIN3 in women referred to colposcopy with minor abnormal cervical cytology low-grade squamous intraepithelial lesions (LSIL) and atypical squamous cells of undermined significance (ASC-US).
|
26932360 |
2016 |
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Study subjects were women enrolled in the atypical squamous cells of undetermined significance (ASC-US) and low-grade squamous intraepithelial lesion (LSIL) triage study who had ≥1 of 11 non-HPV16/18 oncogenic types detected during a 2-year follow-up at 6-month intervals.
|
28052328 |
2017 |
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The risk of persistence or progression of histological LSIL was higher in women with ASC-H or HSIL on the referral cytology and in tobacco users.
|
28255767 |
2017 |
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
ASC-H cytology was classified as either ASC-H or LSIL with some features suggestive of the presence of a concurrent HSIL (LSIL-H).
|
27245707 |
2017 |
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The average risk for CIN3+ was 17% and 19% in HPV 16/18-positive women with ASC-US and LSIL, respectively, and was 5% in hrHPV-positive but HPV 16/18-negative women with either ASC-US or LSIL.
|
27842420 |
2017 |
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ten of the 15 cases were identified as atypical squamous cells - cannot exclude an HSIL (ASC-H) with secondary diagnosis of low-grade squamous intraepithelial lesion (LSIL), while five cases were identified as high-grade squamous intraepithelial lesion (HSIL), and a subsequent biopsy was recommended.
|
29154448 |
2018 |
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cytology reports consisted of HSIL (45.4%), atypical squamous cells of undetermined significance (ASC-US) (16.1%), and LSIL (11.6%), and atypical squamous cells cannot exclude HSIL (ASC-H) (9.3%), squamous cell carcinoma (0.9%), AGC (atypical glandular cells, 0.9%), AIS (0.4%), and NILM (negative for intraepithelial lesion or malignancy, 15.4%).
|
29854761 |
2018 |
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cytological examination revealed 12% of participants had atypical squamous cells of undetermined significance (ASC-US), 8% had low-grade squamous intraepithelial lesions (LSIL), 7% had high-grade squamous intraepithelial lesions (HSIL), and 14% had squamous cell carcinoma (SCC), while 59% of women had a normal cytology.
|
30261268 |
2018 |