|
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
HPV 16 was found the most common HR-HPV type in ASC-US and LSIL whereas HPV 18 was the most common in HSIL.
|
30880699 |
2019 |
|
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Risk of ≥CIN3 and ≥CIN2 associated with the other 13 genotypes varied somewhat for women with ASC-US and LSIL, however, HPV 31, 18, 33/58, 51 and 52 appear to comprise an intermediate risk band.
|
31160073 |
2019 |
|
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ten of the 15 cases were identified as atypical squamous cells - cannot exclude an HSIL (ASC-H) with secondary diagnosis of low-grade squamous intraepithelial lesion (LSIL), while five cases were identified as high-grade squamous intraepithelial lesion (HSIL), and a subsequent biopsy was recommended.
|
29154448 |
2018 |
|
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cytology reports consisted of HSIL (45.4%), atypical squamous cells of undetermined significance (ASC-US) (16.1%), and LSIL (11.6%), and atypical squamous cells cannot exclude HSIL (ASC-H) (9.3%), squamous cell carcinoma (0.9%), AGC (atypical glandular cells, 0.9%), AIS (0.4%), and NILM (negative for intraepithelial lesion or malignancy, 15.4%).
|
29854761 |
2018 |
|
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cytological examination revealed 12% of participants had atypical squamous cells of undetermined significance (ASC-US), 8% had low-grade squamous intraepithelial lesions (LSIL), 7% had high-grade squamous intraepithelial lesions (HSIL), and 14% had squamous cell carcinoma (SCC), while 59% of women had a normal cytology.
|
30261268 |
2018 |
|
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Study subjects were women enrolled in the atypical squamous cells of undetermined significance (ASC-US) and low-grade squamous intraepithelial lesion (LSIL) triage study who had ≥1 of 11 non-HPV16/18 oncogenic types detected during a 2-year follow-up at 6-month intervals.
|
28052328 |
2017 |
|
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The risk of persistence or progression of histological LSIL was higher in women with ASC-H or HSIL on the referral cytology and in tobacco users.
|
28255767 |
2017 |
|
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
ASC-H cytology was classified as either ASC-H or LSIL with some features suggestive of the presence of a concurrent HSIL (LSIL-H).
|
27245707 |
2017 |
|
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The average risk for CIN3+ was 17% and 19% in HPV 16/18-positive women with ASC-US and LSIL, respectively, and was 5% in hrHPV-positive but HPV 16/18-negative women with either ASC-US or LSIL.
|
27842420 |
2017 |
|
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
HPV infection and p16 promoter methylation as predictors of ASC-US/LSIL progression.
|
26335500 |
2016 |
|
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate human papillomavirus (HPV) DNA testing and p16/Ki-67 staining for detecting cervical intraepithelial grade 2 or worse (CIN2+) and CIN3 in women referred to colposcopy with minor abnormal cervical cytology low-grade squamous intraepithelial lesions (LSIL) and atypical squamous cells of undermined significance (ASC-US).
|
26932360 |
2016 |
|
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two samples (1 ASC-US/1 LSIL) were excluded from the analysis due to inconclusive results of the histologic examination.
|
26230097 |
2015 |
|
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two hundred women (150 pre-menopausal and 50 post-menopausal) with ASC- US and LSIL cytology who attended the colposcopy clinic, Thammasat University Hospital, between March 2013 and August 2014 were included.
|
25824759 |
2015 |
|
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
All women with ASC-US/LSIL cytology who were referred to our colposcopy clinic from October 2010 to February 2014 were included.
|
25605209 |
2014 |
|
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Through the use of an immediate colposcopy threshold of ASC-US or worse for HR-HPV positive women and the use of a raised threshold of low-grade squamous intraepithelial lesion (LSIL) or worse for HR-HPV negative women, LBC and HR-HPV cotesting could provide the same effectiveness as LBC testing with HR-HPV triage for ASC-US at baseline tests.
|
24631450 |
2014 |
|
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Literature search-targeted studies where the accuracy of APTIMA HPV and HC2 for detection of underlying CIN2/3+ was assessed concomitantly including verification of all cases of ASC-US and LSIL.
|
22610699 |
2013 |
|
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Considering CIN2+ in women with ASC-US and LSIL, mRNA testing was substantially more specific than the HC2 assay (ratio: 1.98 and 3.36, respectively; P < .001) but was less sensitive (ratio: 0.80 and 0.74, respectively; P < .001).
|
23881840 |
2013 |
|
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In women with high-risk (HR)-HPV-positive atypical squamous cells of undetermined significance (ASC-US) and LSIL, sensitivity and specificity for detection of CIN3 were 90.6% and 48.6%, respectively.
|
22675168 |
2012 |
|
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thirty six of them (37.9%) showed abnormal anal cytology as follows: atypical squamous cells of undetermined significance (ASC-US) in 19 (20.0%), atypical squamous cells but cannot exclude HSIL (ASC-H) in 1 (1.1%), low-grade squamous intraepithelial lesion (LSIL) in 15 (15.8%), and high-grade squamous intraepithelial lesion (HSIL) in 1 (1.1%).
|
22558293 |
2012 |
|
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Liquid-based cytology cases interpreted as high-grade squamous intraepithelial lesion (HSIL); low-grade squamous intraepithelial lesion (LSIL); atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H); and atypical squamous cells of undetermined significance (ASC-US) at Magee-Womens Hospital (Pittsburgh, Pennsylvania) were retrospectively identified for a 36-month period between July 1, 2005, and June 30, 2008, from women 50 years and older who also had hrHPV DNA test results.
|
20670132 |
2010 |
|
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The increased rates of HPV test performance and lower rates of HPV positivity in vaginal ASC-US and LSIL TPPTs compared with similarly abnormal cervical TPPTs were statistically significant (p <.05) by χ analysis.
|
20885164 |
2010 |
|
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Study subjects were 303 women who were HPV18 positive at enrollment into the Atypical Squamous Cells of Undetermined Significance (ASC-US) and Low-Grade Squamous Intraepithelial Lesion (LSIL) Triage Study.
|
19176451 |
2009 |
|
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Primary screening with Hybrid Capture((R)) 2 (HC2) generally detects more than 90% of all CIN2, CIN3 or cancer cases, and is 25% (95% CI): 15-36%) relatively more sensitive than cytology at a cut-off of abnormal squamous cells of undetermined significance (ASC-US) (or low-grade squamous intraepithelial lesions (LSIL) if ASC-US unavailable), but is 6% (95% CI: 4-7%) relatively less specific.
|
18847555 |
2008 |
|
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
HPV-positive rates were determined in cases of low-grade squamous intraepithelial lesion (LSIL) and high-grade squamous intraepithelial lesion (HSIL), and follow-up rates of cervical intraepithelial neoplasia (CIN) were determined in HPV-positive and -negative cases of atypical squamous cells of unknown significance (ASC-US).
|
17091508 |
2006 |
|
Low Grade Squamous Intraepithelial Neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
One hundred seven cases, including 23 negative cases, 34 with low-grade squamous intraepithelial lesion (LSIL), 16 with high-grade squamous intraepithelial lesion (HSIL), 29 with atypical squamous cells of uncertain significance (ASC-US), and 5 cases with ASC suspicious for HSIL (ASC-H), were evaluated for both p16 expression and HPV DNA.
|
15584047 |
2005 |