|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Cell Counting Kit‑8 assay, flow cytometry and tumor xenograft procedures were performed to evaluate the biological role of BRD7 and Bak in breast cancer cells.
|
30592293 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, these results indicate that BRD7 acts as a tumor suppressor in breast cancer and represses the glycolysis and tumor progression through inactivation of HIF1α/LDHA transcription axis.
|
29725006 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
BRD7 expression and c-Myc activation forms a double-negative feedback loop that controls the cell proliferation and tumor growth of nasopharyngeal carcinoma by targeting oncogenic miR-141.
|
29559001 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We identified nineteen putative angiosuppressor genes, one of them being bromodomain containing 7 (BRD7), a gene that has been assigned tumor suppressor properties.
|
28951988 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Bromodomain-containing protein 7 (BRD7) is a tumour suppressor that is known to regulate many pathological processes including cell growth, apoptosis and cell cycle.
|
27957794 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor suppressor bromodomain-containing protein 7 cooperates with Smads to promote transforming growth factor-β responses.
|
27270427 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, ectopic expression of miR-141 can significantly promote cell proliferation and inhibit apoptosis in NPC, and rescuing the expression of miR-141 in BRD7-overexpressing NPC cells could partially reverse the tumor suppressive effect of BRD7 on cell proliferation and tumor growth in vitro and in vivo.
|
27010857 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
On the other hand, hepatoma cell proliferation is attenuated by the bromodomain containing 7 (BRD7), a tumor suppressor, through a negative feedback regulatory mechanism.
|
26620707 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings are consistent with a tumor suppressor role for BRD7 in lung adenocarcinoma tumorigenesis.
|
27580131 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, we identified that bromodomain-containing protein 7 (BRD7), a new tumor suppressor gene, was a direct target of miR-300.
|
26010572 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, BRD7 is a tumor suppressor in osteosarcoma, and the BRD7 mutant resistant to degradation by APC/C is more efficient than the wild-type protein at suppressing proliferation, colony formation, and tumor growth of osteosarcoma in vitro and in vivo.
|
24840027 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, we found that tumor suppressive effects of BRD7 are independent to the presence of p53 activity in ovarian cancer cells.
|
24198243 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Through mRNA microarray analysis, we found that miR-200c inhibits the expression of BRD7, which was recently reported as a potential tumor suppressor gene.
|
22015043 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
BRD7 is a candidate tumour suppressor gene required for p53 function.
|
20228809 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Nested methylation-specific PCR and RT-PCR were employed to detect the methylation status of BRD7 promoter and the mRNA expression of BRD7 gene in tumor cell lines as well as clinical samples.
|
18778484 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, the present study indicated that BRD7 inhibited G1-S progression by transcriptionally regulating some important molecules involved in ras/MEK/ERK and Rb/E2F pathways and suggested that BRD7 may present a promising candidate of NPC trade mark associated tumor suppressor gene.
|
15137061 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
NGX6, NAG-7 and BRD7 genes are tumor related genes, which have been newly cloned by positional candidate cloning strategy.
|
12918109 |
2003 |
|
Malignant granular cell tumor
|
0.100 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
Nasopharyngeal carcinoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Additionally, the expression of c-Myc was positively correlated with that of miR-141 and the clinical stages of NPC patients and negatively associated with the expression of BRD7.
|
29559001 |
2018 |
|
Nasopharyngeal carcinoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
The bromodomain-containing protein 7 (BRD7) was first identified as a tumor suppressor in nasopharyngeal carcinoma and has critical roles in cancer development and progression.
|
29725006 |
2018 |
|
Nasopharyngeal carcinoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
Our findings demonstrate that the BRD7/miR-141/PTEN/AKT axis has critical roles in the progression of NPC and provide some promising targets for the diagnosis and treatment of NPC.
|
27010857 |
2016 |
|
Nasopharyngeal carcinoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Loss of expression of BRD7 has been observed in breast cancers and nasopharyngeal carcinomas due to promoter hypermethylation.
|
25743841 |
2015 |
|
Nasopharyngeal carcinoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
BRD7 is a NPC-associated bromodomain gene that exhibits a much higher-level of mRNA expression in normal than in NPC biopsies and cell lines.
|
18778484 |
2008 |
|
Nasopharyngeal carcinoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
We also found that over-expression of BRD7 can inactivate the c-jun and p-ERK1/2 after being treated with EGF in HNE1 cells.
|
17458518 |
2007 |
|
Nasopharyngeal carcinoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these results will help to better understand the role of the BRD7 gene in signal-dependent transcriptional regulation, and to develop new reagents for therapeutic upregulation of the BRD7 gene in NPC.
|
16792505 |
2006 |