GRM2, glutamate metabotropic receptor 2, 2912

N. diseases: 104; N. variants: 1
Disease: Movement Disorders ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026650
Disease: Movement Disorders
Movement Disorders 		0.010 Biomarker group BEFREE The evidence that AMPA-induced intracellular Zn<sup>2+</sup> dysregulation causes movement disorder via nigrostriatal dopaminergic neurodegeneration suggests that AMPA receptors, probably Ca<sup>2+</sup>- and Zn<sup>2+</sup>-permeable GluR2-lacking AMPA receptors are potential targets for overcoming Parkinson's syndrome. 30176255 2018