This study focuses on the effect of exercise therapy in reducing the concentration of extracellular glutamate (Glu) in the striatum in a rat PD model by upregulating the expression of group II metabotropic Glu receptor (mGluR2/3), so as to alleviate motor dysfunction in the rat PD model.
Activation of calcium-impermeable GluR2-containing AMPA receptors in the lateral habenula produces antidepressant-like effects in a rodent model of Parkinson's disease.
The evidence that AMPA-induced intracellular Zn<sup>2+</sup> dysregulation causes movement disorder via nigrostriatal dopaminergic neurodegeneration suggests that AMPA receptors, probably Ca<sup>2+</sup>- and Zn<sup>2+</sup>-permeable GluR2-lacking AMPA receptors are potential targets for overcoming Parkinson's syndrome.