GRM2, glutamate metabotropic receptor 2, 2912

N. diseases: 104; N. variants: 1
Disease: Drug Dependence ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1510472
Disease: Drug Dependence
Drug Dependence 		0.030 Biomarker group BEFREE These results indicate that withdrawal-induced mGluR2/3 downregulation alters neural plasticity after morphine exposure, which may be a mechanism contributing to drug addiction. 30315852 2019
CUI: C1510472
Disease: Drug Dependence
Drug Dependence 		0.030 Biomarker group BEFREE In this respect, among glutamatergic receptors special attention is paid to the group II of metabotropic glutamatergic receptors (mGlu2/3R) which are involved in the transition from drug use to drug addiction including the relapse mechanisms. 28988614 2017
CUI: C1510472
Disease: Drug Dependence
Drug Dependence 		0.030 Biomarker group BEFREE Metabotropic glutamate 2 and 3 (mGluR2/3) receptors are implicated in drug addiction as they limit excessive glutamate release during relapse. 28251297 2017