|
Acoustic Neuroma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Immunohistochemical staining for B7-H1, CD8+, CD3+, and CD4+ lymphocytes were performed on 48 fresh-frozen vestibular schwannoma tissue specimens.
|
20601920 |
2010 |
|
Acoustic Neuroma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The authors hypothesized that PD-L1 is a key regulator of the VS immune microenvironment.
|
31585433 |
2019 |
|
Actinic cheilitis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
We assessed PD-L1 expression in tumor cells (TC) and immune cells (IC) of squamous-cell carcinoma (SCC) and adenocarcinoma (AC) patients.
|
28959173 |
2017 |
|
Actinic cheilitis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
PD-L1 and HLA-G expression in neoplastic cells/keratinocytes and stroma/connective tissue was significantly higher in LSCC and AC, compared to HLM (p<0.05).
|
30468994 |
2019 |
|
Actinic cheilitis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
PD-L1 expression was detected in 7% of TC tumors; all AC tumors were PD-L1 negative.
|
31299636 |
2019 |
|
Actinic keratosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
KA showed significantly higher numbers of CD4+ and FOXp3+ cells as well as lower numbers of CD8+ cells in comparison with invasive cSCC. cSCC expressed significantly more PD-L1 in comparison with AK and KA.
|
29799076 |
2018 |
|
Actinic keratosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
PD-L1 expression of tumour cells as well as tumour-infiltrating cells (TILs) was significantly higher in KA and cSCC when compared to AK and BD (P = 0.00028 and P = 0.00033, respectively).
|
28501937 |
2017 |
|
Active tuberculosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Programmed death ligand 1 is over-expressed by neutrophils in the blood of patients with active tuberculosis.
|
21509782 |
2011 |
|
Acute GVH disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
We also performed single gene analyses of factors associated with tolerance (programmed death ligand-1 [PDL1], indoleamine 2,3 dioxygenase [IDO1], and T cell immunoreceptor with Ig and ITIM domains [TIGIT]) and found that significantly higher expression levels of these aGVHD inhibitory genes (PDL1, IDO1, TIGIT) at aGVHD onset became decreased in the steroid-refractory state.
|
31393854 |
2019 |
|
Acute GVH disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The + 7 days/+ 14 days B7H1/B7H3 and + 28 days ST2 serum levels were higher in patients with aGVHD who underwent haplo-HSCT.
|
30725359 |
2019 |
|
Acute GVH disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that systemic treatment with PD-L1 may be a potential strategy to prevent or ameliorate aGVHD.
|
30927016 |
2019 |
|
Acute hepatitis C
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PD-1 and PD-L1 expression was studied on T cells and dendritic cells, respectively, of 14 patients with acute hepatitis C and different evolutions of infection.
|
18280607 |
2008 |
|
Acute infectious disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Though, how PDL-1 blocking at the time of priming affects the quality of CD8 T cell response to acute infections is not well understood and remains controversial.
|
22808056 |
2012 |
|
Acute intermittent porphyria
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients with type 2 AIP showed pancreatic ductal staining for PD-L1 and IDO1 in 69% (24/35) and 60% (15/25) of cases, respectively.
|
31135488 |
2019 |
|
Acute interstitial pneumonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients with type 2 AIP showed pancreatic ductal staining for PD-L1 and IDO1 in 69% (24/35) and 60% (15/25) of cases, respectively.
|
31135488 |
2019 |
|
Acute lymphocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The higher expression of immune checkpoint molecules, in particular, CTLA-4 and PD-L1 are associated with a poorer prognosis in ALL, suggesting that selective use of the immune checkpoint blockade might improve the clinical outcomes in patients with ALL.
|
31570447 |
2019 |
|
Acute migraine
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study we evaluated the expression and role of PD-L1/PD-1 in the trigeminal ganglia in an animal model of acute migraine.
|
31640402 |
2020 |
|
Acute monocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Enhanced Anti-Leukemic Effects through Induction of Immunomodulating Microenvironment by Blocking CXCR4 and PD-L1 in an AML Mouse Model.
|
30204524 |
2019 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Compared with healthy volunteers, the percentages of PD-1-expressing CD4<sup>+</sup> lymphocytes and PD-L1-expressing CD14<sup>+</sup> monocytes were increased in patients with AP on days 1 and 3 after onset, especially those with infectious complications.
|
28705256 |
2017 |
|
Acute viral encephalitis
|
0.010 |
Biomarker
|
group |
BEFREE |
The PD-1: PD-L1 pathway promotes development of brain-resident memory T cells following acute viral encephalitis.
|
28407741 |
2017 |
|
Adamantinous Craniopharyngioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We mapped and quantified PD-L1 and PD-1 expression in ACP and PCP resections using immunohistochemistry, immunofluorescence, and RNA in situ hybridization.
|
29509940 |
2018 |
|
Addison's disease due to autoimmunity
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Other gene polymorphisms contribute to the genetic risk for AAD, including CIITA (MHC class II transactivator), the master regulator of MHC class II expression, cytotoxic T-lymphocyte antigen-4 (CTLA-4), PTPN22, STAT4, PD-L1, NALP1, FCRL3, GPR174, GATA3, NFATC1, CYP27B1 and the vitamin D receptor.
|
27211051 |
2016 |
|
Addison's disease due to autoimmunity
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We confirm the role of PD-L1 variants in GD susceptibility and extend these findings to demonstrate association in two Northern European patient cohorts with AAD.
|
19850680 |
2009 |
|
Addison's disease due to autoimmunity
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Gene variants known to contribute to Autoimmune Addison's disease (AAD) susceptibility include those at the MHC, MICA, CIITA, CTLA4, PTPN22, CYP27B1, NLRP-1 and CD274 loci.
|
24614117 |
2014 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
PD-L1 expression was more frequent in medullary and typical adenocarcinoma than in mucinous adenocarcinoma based on combined positive scores.
|
31152546 |
2019 |