Compared with the control group, the striatal mGluR2/3 protein expression of the PD group was significantly downregulated (<i>P</i> < 0.01); compared with the PD group, the striatal mGluR2/3 protein expression of the PD + exercise group was significantly upregulated (<i>P</i> < 0.05); compared with the control group, the striatal mGluR3 mRNA expression of the PD group was significantly downregulated (<i>P</i> < 0.01); compared with the PD group, the striatal mGluR3 mRNA expression of the PD + exercise group was significantly upregulated (<i>P</i> < 0.01); 6-OHDA damage and exercise intervention had no significant effect on the striatal mGluR2 mRNA expression (<i>P</i> > 0.05).