GRM4, glutamate metabotropic receptor 4, 2914

N. diseases: 54; N. variants: 5
Disease: Medulloblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma 		0.020 Biomarker disease BEFREE These drugs appear to display pleiotropic effect on tumor cells, affecting proliferation, differentiation, and response to chemotherapy. mGlu1 and mGlu4 receptors could also be targeted by potential anticancer agents in the treatment of malignant gliomas and medulloblastoma, but extensive research is required for target validation. 29525720 2018
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma 		0.020 Biomarker disease LHGDN These data suggest that mGlu4 receptor enhancers are promising drugs for the treatment of medulloblastomas. 16899734 2006